Risk profiling for cirrhosis and hepatocellular carcinoma in HFE hemochromatosis using mobilizable iron stores and alcohol consumption

• Published in: Scientific reports Vol. 15; no. 1; pp. 16011 - 8
• Main Authors: Mitchell, Natasha D. P., Pierre, Timothy G. St, Ramm, Louise E., Ramm, Grant A., Olynyk, John K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4020/4021; 692/4020/4021/1607/1604; 692/4020/4021/1607/1610; Adult; Aged; Alcohol; Alcohol Drinking - adverse effects; Alcohol use; Alcohols; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cirrhosis; Diagnosis; Female; Hemochromatosis; Hemochromatosis - complications; Hemochromatosis - genetics; Hemochromatosis - metabolism; Hemochromatosis Protein - genetics; Hemochromatosis Protein - metabolism; Hepatic iron concentration (HIC); Hepatic iron index (HII); Hepatocellular carcinoma; Hepatocellular carcinoma (HCC); HFE hemochromatosis (HH); Humanities and Social Sciences; Humans; Iron; Iron - metabolism; Liver cancer; Liver cirrhosis; Liver Cirrhosis - epidemiology; Liver Cirrhosis - etiology; Liver Cirrhosis - metabolism; Liver Neoplasms - epidemiology; Liver Neoplasms - etiology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Middle Aged; Mobilizable iron (MobFe); multidisciplinary; Retrospective Studies; Risk Factors; ROC Curve; Science; Science (multidisciplinary); HFE hemochromatosis (HH); Mobilizable iron (MobFe); Hepatic iron index (HII); Hepatocellular carcinoma (HCC); Hepatic iron concentration (HIC)

HFE hemochromatosis (HH) may cause cirrhosis and hepatocellular carcinoma (HCC). Progression to these endpoints depends on the severity of iron overload and cofactors, such as alcohol. We evaluated alcohol and iron-related risk factors in relation to cirrhosis at diagnosis and future development of...