Experience with perioperative pirfenidone for lung cancer surgery in patients with idiopathic pulmonary fibrosis

• Published in: Surgery today (Tokyo, Japan) Vol. 45; no. 10; pp. 1263 - 1270
• Main Authors: Iwata, Takekazu, Yoshida, Shigetoshi, Nagato, Kaoru, Nakajima, Takahiro, Suzuki, Hidemi, Tagawa, Tetsuzo, Mizobuchi, Teruaki, Ota, Satoshi, Nakatani, Yukio, Yoshino, Ichiro
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.10.2015
• Subjects: Acute Disease; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents - administration & dosage; Disease Progression; Feasibility Studies; Female; Humans; Idiopathic Pulmonary Fibrosis - complications; Idiopathic Pulmonary Fibrosis - prevention & control; Idiopathic Pulmonary Fibrosis - surgery; Lung Neoplasms - complications; Lung Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Perioperative Care; Postoperative Complications - prevention & control; Pyridones - administration & dosage; Retrospective Studies; Surgery; Surgical Oncology; Treatment Outcome; Acute exacerbation; Pirfenidone; Idiopathic pulmonary fibrosis; Lung cancer; Surgery

Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive diffuse lung disease associated with an increased risk of lung cancer. Patients with IPF sometimes develop a life-threatening acute exacerbation of IPF (AE-IPF) after lung cancer surgery. In this retrospective study, pirfenidone, an antifi...