The RIIβ Regulatory Subunit of Protein Kinase A Binds to cAMP Response Element: An Alternative cAMP Signaling Pathway

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 95; no. 12; pp. 6687 - 6692
• Main Authors: Srivastava, Rakesh K., Lee, Youl Nam, Noguchi, Kohei, Park, Yun Gyu, Matthew J. C. Ellis, Jeong, Jin-Sook, Kim, Se Nyun, Cho-Chung, Yoon S.
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences of the United States of America 09.06.1998; National Acad Sciences; The National Academy of Sciences
• Subjects: Antibodies; Biological Sciences; Cell growth; Cell lines; Cell nucleus; COS cells; Gels; Genes; NIH 3T3 cells; Oligonucleotides; Proteins

cAMP, through the activation of cAMP-dependent protein kinase (PKA), is involved in transcriptional regulation. In eukaryotic cells, cAMP is not considered to alter the binding affinity of CREB/ATF to cAMP-responsive element (CRE) but to induce serine phosphorylation and consequent increase in trans...