Neural functions of bisecting GlcNAc

• Published in: Glycoconjugate journal Vol. 35; no. 4; pp. 345 - 351
• Main Authors: Kizuka, Yasuhiko, Taniguchi, Naoyuki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2018; Springer Nature B.V
• Subjects: Acetylglucosamine - biosynthesis; Acetylglucosamine - chemistry; Acetylglucosamine - metabolism; Alzheimer Disease - metabolism; Alzheimer Disease - therapy; Alzheimer's disease; Amyloid; Amyloid Precursor Protein Secretases - metabolism; Animals; Biochemistry; Biomedical and Life Sciences; Brain - metabolism; Endosomes; Enzymes; High-throughput screening; Humans; Life Sciences; Localization; Lysosomes; Mini-Review; Models, Biological; N-Acetylglucosinyldiphosphodolichol N-acetylglucosaminyltransferase; Nervous system; Pathology; Up-Regulation; β-Site APP-cleaving enzyme 1; BACE1; Bisecting GlcNAc; Alzheimer’s disease; GnT-III; Glycan; N-Glycan

Bisecting GlcNAc, a branch structure in N -glycan, has unique functions and is involved in several diseases including Alzheimer’s disease (AD). In this review, we provide an overview of the biosynthesis of bisecting GlcNAc and its physiological and pathological functions, particularly in the nervous...