Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol

• Published in: Chest Vol. 109; no. 4; p. 953
• Main Authors: Kalra, S, Swystun, V A, Bhagat, R, Cockcroft, D W
• Format: Journal Article
• Language: English
• Published: United States 01.04.1996
• Subjects: Administration, Inhalation; Adrenergic beta-Agonists - administration & dosage; Adrenergic beta-Agonists - therapeutic use; Adult; Aged; Albuterol - administration & dosage; Albuterol - analogs & derivatives; Albuterol - therapeutic use; Anti-Asthmatic Agents - administration & dosage; Anti-Asthmatic Agents - therapeutic use; Asthma - drug therapy; Beclomethasone - administration & dosage; Beclomethasone - therapeutic use; Bronchial Provocation Tests; Bronchoconstriction - drug effects; Bronchoconstrictor Agents; Bronchodilator Agents - administration & dosage; Bronchodilator Agents - therapeutic use; Budesonide; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume - drug effects; Humans; Male; Methacholine Chloride; Middle Aged; Placebos; Pregnenediones - administration & dosage; Pregnenediones - therapeutic use; Salmeterol Xinafoate; Tachyphylaxis

Twice-daily inhaled salmeterol produces rapid reduction in its acute bronchoprotective effect against methacholine in patients with mild asthma. This investigation examined this effect in patients with moderate asthma who were using inhaled corticosteroids. Eight asthmatic volunteers who required in...