Plasma cortisol levels before and during low-dose hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock

• Published in: Intensive care medicine Vol. 26; no. 12; pp. 1747 - 1755
• Main Authors: OPPERT, Michael, REINICKE, Albrecht, GRÄF, Klaus-Jürgen, BARCKOW, Detlef, FREI, Ulrich, ECKARDT, Kai-Uwe
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.12.2000; Berlin Springer Nature B.V; Springer-Verlag
• Subjects: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; Cardiac Output - drug effects; Catecholamines; Drug Administration Schedule; Drug dosages; Drug Monitoring; Drug Therapy, Combination; Emergency and intensive care: infection, septic shock; Female; Hemodynamics; Hemodynamics - drug effects; Hormones; Humans; Hydrocortisone - administration & dosage; Hydrocortisone - blood; Hydrocortisone - pharmacology; Infections; Inflammation; Infusions, Intravenous; Intensive care; Intensive care medicine; Male; Medical sciences; Middle Aged; Mortality; Observational studies; Original; Plasma; Prospective Studies; Pulmonary arteries; Sepsis; Shock, Septic - drug therapy; Shock, Septic - metabolism; Shock, Septic - mortality; Shock, Septic - physiopathology; Steroids; Treatment Outcome; Vasoconstrictor Agents - therapeutic use; Berlin Germany; Germany; Shock; Human; Corticosteroid; Concentration factor; Low dose; Cardiovascular disease; Hydrocortisone; Biological activity; Blood plasma; Infection; Sepsis syndrome; Chemotherapy; Treatment; Adrenal hormone; Bacteriosis; Hemodynamics; Pharmacokinetics

To compare cortisol levels during "low-dose" hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Prospective observational st...