Intradialytic optical assessment of C-mannosyl tryptophan removal using spent dialysate

• Published in: Scientific reports Vol. 15; no. 1; pp. 20052 - 12
• Main Authors: Paats, Joosep, Adoberg, Annika, Leis, Liisi, Arund, Jürgen, Lauri, Kai, Luman, Merike, Tanner, Risto, Holmar, Jana, Pilt, Kristjan, Fridolin, Ivo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.06.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4022; 692/53; Adult; Aged; Biomarkers - blood; Blood; C-glycosyltryptophan; C-mannosyl tryptophan; Chromatography; Chromatography, High Pressure Liquid; Dialysate; Dialysis Solutions - chemistry; End stage kidney disease; Female; Hemodialysis; High pressure; Humanities and Social Sciences; Humans; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Kidneys; Liquid chromatography; Male; Middle Aged; multidisciplinary; Renal Dialysis - methods; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - therapy; Science; Science (multidisciplinary); Spectrophotometric analysis; Spectrophotometry; Tryptophan; Tryptophan - analogs & derivatives; Tryptophan - blood; Uremic solutes; Uremic solutes; Hemodialysis; End stage kidney disease; Spectrophotometric analysis; C-mannosyl tryptophan; C-glycosyltryptophan

C-mannosyl tryptophan (CMW), also known as C-glycosyltryptophan, is a novel biomarker that is strongly correlated to chronic kidney disease (CKD) incidence and progression risk and mortality among earlier stages of CKD patients prior to end stage kidney disease. This study determined concentrations...