Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination

• Published in: Nature communications Vol. 16; no. 1; pp. 6382 - 23
• Main Authors: He, Yongxiang, Li, Jiong, Zheng, Wei, Liu, Junhong, Dong, Zhaojun, Yang, Lu, Tang, Shuting, Zou, Yanping, Gao, Tianyu, Yang, Yuqian, Mo, Zhenpeng, Wang, Shuming, He, Yuehua, Tang, Changyong, Luo, Jianhong, Zhao, Jingwei, Guo, Guoqing, Li, Huiliang, Xiao, Lin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 14/19; 14/28; 631/378; 631/378/2606; 64/60; 9/30; 9/74; Abnormalities; Animals; Autism; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - metabolism; Autism Spectrum Disorder - physiopathology; Autistic Disorder - genetics; Brain; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - metabolism; Cells; Cortex (barrel); Disease Models, Animal; Excitability; Gamma Rhythm - physiology; Humanities and Social Sciences; Information processing; Interneurons; Interneurons - metabolism; Interneurons - physiology; Localization; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Knockout; multidisciplinary; Mutation; Myelin; Myelin Sheath - metabolism; Myelin Sheath - pathology; Myelination; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neural stem cells; Neuroplasticity; Oligodendroglia - metabolism; Oscillations; Parvalbumin; Parvalbumins - metabolism; Phenotypes; Plastic properties; Plasticity; Proteins; Science; Science (multidisciplinary); Sensory discrimination; Sensory integration; Somatosensory cortex; Somatosensory Cortex - metabolism; Texture recognition; Therapeutic targets

Whether and how myelin plasticity, an emerging new form of brain plasticity, is involved in autism spectrum disorder (ASD) remains unknown. Here, we identify deficits in oligodendrocyte (OL) generation and myelination in the barrel cortex (BC) of the male NL3-R451C -KI mouse model of ASD. These mice...