Synovial cell production of IL-26 induces bone mineralization in spondyloarthritis

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 95; no. 7; pp. 779 - 787
• Main Authors: Heftdal, Line Dam, Andersen, Thomas, Jæhger, Ditte, Woetmann, Anders, Østgård, René, Kenngott, Elisabeth E., Syrbe, Uta, Sieper, Joachim, Hvid, Malene, Deleuran, Bent, Kragstrup, Tue W.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2017; Springer Nature B.V
• Subjects: Actin; Adult; Aged; Arthritis; Biomedical and Life Sciences; Biomedicine; Bone marrow; Cells, Cultured; Enzyme-linked immunosorbent assay; Female; Fibroblasts - immunology; Fibroblasts - pathology; Flow cytometry; Helper cells; Human Genetics; Humans; Inflammation; Inflammatory diseases; Interleukins - analysis; Interleukins - blood; Interleukins - immunology; Internal Medicine; Joint diseases; Leukocytes (mononuclear); Lymphocytes T; Male; Middle Aged; Mineralization; Molecular Medicine; Original Article; Osteoblasts; Osteoblasts - immunology; Osteoblasts - pathology; Osteogenesis; Plasma; Rheumatic diseases; Secretion; Smooth muscle; Spondylarthritis - blood; Spondylarthritis - immunology; Spondylarthritis - pathology; Synovial fluid; Synovial Fluid - cytology; Synovial Fluid - immunology; Synoviocytes; Synoviocytes - immunology; Synoviocytes - pathology; Synovium; Th17 Cells - immunology; Th17 Cells - pathology; Tumor necrosis factor; Tumor Necrosis Factor-alpha - immunology; Vitamin D; Young Adult; Fibroblasts; IL-26; TNF-α; Spondyloarthritis; Osteoblasts

Spondyloarthritis (SpA) is characterized by inflammation and new bone formation and can be treated by inhibition of the proinflammatory cytokines TNF-α and IL-17A. IL-26 is considered a proinflammatory cytokine, predominantly related to Th17 cells. In the present study, we investigate IL-26 expressi...