Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics

• Published in: Clinical pharmacokinetics Vol. 55; no. 7; pp. 789 - 805
• Main Authors: Gill, Katherine L., Machavaram, Krishna K., Rose, Rachel H., Chetty, Manoranjenni
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2016; Springer Nature B.V
• Subjects: Age Factors; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacokinetics; Body Weights and Measures; Comorbidity; Dose-Response Relationship, Drug; Drug Interactions; Ethnic Groups; Histocompatibility Antigens Class I - metabolism; Humans; Internal Medicine; Lymphatic System - metabolism; Medicine; Medicine & Public Health; Models, Biological; Pharmacology/Toxicology; Pharmacotherapy; Polymorphism, Genetic; Receptors, Fc - metabolism; Review Article; Severity of Illness Index; Sex Factors; Omalizumab; Alemtuzumab; Infliximab; Adalimumab; Rheumatoid Arthritis Patient
• ISSN: 0312-5963; 1179-1926; 1179-1926
• DOI: 10.1007/s40262-015-0361-4

Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients attain suitable drug exposure to achieve efficacy and avoid toxicity. Inter-subject variability in the pharmacokinetics of therapeutic monoclonal antibodies (mAbs) is genera...