Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function

• Published in: Neuropharmacology Vol. 51; no. 2; pp. 374 - 385
• Main Authors: Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Fujiwara, Remie A., James, Larry C., Williams, Robert D., Stock, Jeffrey L., McNeish, John D., Strick, Christine A., Menniti, Frank S., Schmidt, Christopher J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2006
• Subjects: Amphetamine; Amphetamine - pharmacology; Animals; Avoidance Learning; Behavior, Animal; Biogenic Monoamines - metabolism; Brain - metabolism; Central Nervous System Stimulants - pharmacology; Conditioned avoidance; Conditioning, Operant; Corpus Striatum - enzymology; Corpus Striatum - physiology; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Maze Learning; Methamphetamine; Methamphetamine - pharmacology; Mice; Mice, Knockout; MK-801; Motor Activity - drug effects; PCP; Phencyclidine - pharmacology; Phosphoric Diester Hydrolases - genetics; Phosphoric Diester Hydrolases - physiology; Schizophrenia; Striatum; Striatum; MK-801; Amphetamine; Methamphetamine; Schizophrenia; PCP; Conditioned avoidance

PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A −/−) were characterized both behaviorally and neurochem...