Altered Death Receptor Signaling Promotes Epithelial-to-Mesenchymal Transition and Acquired Chemoresistance

• Published in: Scientific reports Vol. 2; no. 1; p. 539
• Main Authors: Antoon, James W., Lai, Rongye, Struckhoff, Amanda P., Nitschke, Ashley M., Elliott, Steven, Martin, Elizabeth C., Rhodes, Lyndsay V., Yoon, Nam Seung, Salvo, Virgilio A., Shan, Bin, Beckman, Barbara S., Nephew, Kenneth P., Burow, Matthew E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.07.2012; Nature Publishing Group
• Subjects: 631/67/70; 631/80/82; 631/80/86; 692/420/755; Animals; Apoptosis; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cell Line, Tumor; Cell Survival - genetics; Cell Transformation, Neoplastic - genetics; Chemoresistance; Chemotherapy; Cluster Analysis; Death; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition - genetics; Estrogen Receptor alpha - metabolism; Estrogen receptors; Estrogens; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humanities and Social Sciences; Humans; Mesenchyme; Mice; Mice, Nude; multidisciplinary; Multidrug resistance; NF-kappa B - metabolism; NF-κB protein; Receptors, Death Domain; Receptors, Tumor Necrosis Factor - metabolism; Science; Signal Transduction; Tumor necrosis factor; Tumor Necrosis Factor-alpha - pharmacology; Tumor Necrosis Factor-alpha - toxicity; Tumor necrosis factor-TNF; Xenograft Model Antitumor Assays

Altered death receptor signaling and resistance to subsequent apoptosis is an important clinical resistance mechanism. Here, we investigated the role of death receptor resistance in breast cancer progression. Resistance of the estrogen receptor alpha (ER)-positive, chemosensitive MCF7 breast cancer...