Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity

• Published in: Scientific reports Vol. 5; no. 1; p. 11338
• Main Authors: Chen, Xing, Clarence Yan, Chenggang, Luo, Cai, Ji, Wen, Zhang, Yongdong, Dai, Qionghai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.06.2015; Nature Publishing Group
• Subjects: 631/114/2397; 631/337/384/2568; 631/553/2695; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Computational Biology; Computer applications; Computer Simulation; Female; Gene Library; Gene Regulatory Networks - genetics; Genetic Predisposition to Disease; Humanities and Social Sciences; Humans; Lung cancer; Lung Neoplasms - genetics; Male; Mathematical models; Models, Biological; multidisciplinary; Prediction models; Preschool children; RNA, Long Noncoding - genetics; Science

Increasing evidence has indicated that plenty of lncRNAs play important roles in many critical biological processes. Developing powerful computational models to construct lncRNA functional similarity network based on heterogeneous biological datasets is one of the most important and popular topics i...