Detection of Mycobacterium tuberculosis DNA on the oral mucosa of tuberculosis patients

• Published in: Scientific reports Vol. 5; no. 1; p. 8668
• Main Authors: Wood, Rachel C., Luabeya, Angelique K., Weigel, Kris M., Wilbur, Alicia K., Jones-Engel, Lisa, Hatherill, Mark, Cangelosi, Gerard A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.03.2015; Nature Publishing Group
• Subjects: 45/22; 45/77; 631/326/2521; 692/53/2421; 692/699/255/1856; Adult; Case-Control Studies; Deoxyribonucleic acid; Diabetes Mellitus - microbiology; DNA; DNA, Bacterial - analysis; Female; Humanities and Social Sciences; Humans; Male; Middle Aged; Mouth Mucosa - microbiology; Mucosa; multidisciplinary; Mycobacterium tuberculosis - genetics; Polymerase chain reaction; Science; Science (multidisciplinary); Sensitivity and Specificity; Sputum; Sputum - microbiology; Tuberculosis; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - microbiology

Diagnosis of pulmonary tuberculosis (TB) usually includes laboratory analysis of sputum, a viscous material derived from deep in the airways of patients with active disease. As a diagnostic sample matrix, sputum can be difficult to collect and analyze by microbiological and molecular techniques. An...