Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion

• Published in: The Journal of immunology (1950) Vol. 186; no. 3; pp. 1799 - 1808
• Main Authors: Renaud, Stephen J, Cotechini, Tiziana, Quirt, Jill S, Macdonald-Goodfellow, Shannyn K, Othman, Maha, Graham, Charles H
• Format: Journal Article
• Language: English
• Published: United States 01.02.2011
• Subjects: Abortion, Spontaneous - immunology; Abortion, Spontaneous - pathology; Abortion, Spontaneous - physiopathology; Animals; Disease Models, Animal; Embryo Loss - immunology; Embryo Loss - pathology; Embryo Loss - physiopathology; Female; Fetal Death - immunology; Fetal Death - pathology; Fetal Death - physiopathology; Hemodynamics - immunology; Inflammation - immunology; Inflammation - pathology; Inflammation - physiopathology; Lipopolysaccharides - administration & dosage; Male; Maternal-Fetal Exchange - immunology; Placenta - blood supply; Pregnancy; Rats; Rats, Wistar; Uterus - blood supply

Abnormal maternal inflammation during pregnancy is associated with spontaneous pregnancy loss and intrauterine fetal growth restriction. However, the mechanisms responsible for these pregnancy outcomes are not well understood. In this study, we used a rat model to demonstrate that pregnancy loss res...