Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways

• Published in: International journal of molecular sciences Vol. 24; no. 16; p. 12759
• Main Authors: Gu, Qingqing, Orgil, Buyan-Ochir, Bajpai, Akhilesh Kumar, Chen, Yufeng, Ashbrook, David G, Starlard-Davenport, Athena, Towbin, Jeffrey A, Lebeche, Djamel, Purevjav, Enkhsaikhan, Sheng, Hongzhuan, Lu, Lu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.08.2023; MDPI
• Subjects: Animals; BXD family; Carbohydrate Metabolism; Cardiac function; cardiac physiology; Cardiomyocytes; Cardiomyopathy; Cell cycle; Electrocardiography; Gene loci; Genomes; Glucose; glucose metabolism; Insulin resistance; Ischemia; Kinases; Metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Myocytes, Cardiac; Physiology; Protein Serine-Threonine Kinases; Proteins; Signal transduction; systems genetics; Tnni3k; systems genetics; BXD family; Tnni3k; glucose metabolism; cardiac physiology

Troponin-I interacting kinase encoded by the gene is expressed in nuclei and Z-discs of cardiomyocytes. Mutations in were identified in patients with cardiac conduction diseases, arrhythmias, and cardiomyopathy. We performed cardiac gene expression, whole genome sequencing (WGS), and cardiac functio...