Association of p53 codon 72 polymorphism and survival of North Indian lung cancer patients treated with platinum-based chemotherapy

• Published in: Molecular biology reports Vol. 43; no. 12; pp. 1383 - 1394
• Main Authors: Kumari, Ankita, Bahl, Charu, Singh, Navneet, Behera, Digambar, Sharma, Siddharth
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2016; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Animal Anatomy; Animal Biochemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; apoptosis; Biomedical and Life Sciences; carcinogenesis; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - mortality; Case-Control Studies; Chemotherapy; Codon; confidence interval; DNA damage; DNA repair; Drug Resistance, Neoplasm; drug therapy; Female; females; Genetic Association Studies; Genetic Predisposition to Disease; genotype; Genotype & phenotype; genotyping; Histology; Humans; India; Kaplan-Meier Estimate; Life Sciences; Lung cancer; lung neoplasms; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - mortality; Male; males; Medical prognosis; Middle Aged; Morphology; odds ratio; Original Article; patients; Platinum Compounds - pharmacology; Platinum Compounds - therapeutic use; polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Prognosis; Proportional Hazards Models; regression analysis; restriction fragment length polymorphism; risk; survival rate; Treatment Outcome; Tumor Suppressor Protein p53 - genetics; Young Adult; Genotype; Polymorphisms; 53 codon 72; Survival; Lung cancer; p53 codon 72

p 53 helps in maintaining genomic stability by undergoing cellular arrest, DNA repair or cellular apoptosis during DNA damage. So, as to find the association of p 53 Arg 72 Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic varian...