Association studies of 19 candidate SNPs with sporadic Alzheimer’s disease in the North Chinese Han population

• Published in: Neurological sciences Vol. 33; no. 5; pp. 1021 - 1028
• Main Authors: Yuan, Quan, Chu, Changbiao, Jia, Jianping
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.10.2012; Springer Nature B.V
• Subjects: Aged; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E4; Apolipoprotein E4 - genetics; Asian Continental Ancestry Group - genetics; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Linkage disequilibrium; Male; Medicine; Medicine & Public Health; Membrane Proteins - genetics; Neurodegenerative diseases; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Polymorphism, Single Nucleotide; Psychiatry; Replication; Risk Factors; Sialic Acid Binding Ig-like Lectin 3 - genetics; Single-nucleotide polymorphism; Replication; Genome-wide association studies (GWAS); rs3826656; GOLPH2; Alzheimer’s disease; Polymorphisms

Genome-wide association studies (GWAS) identified multiple single-nucleotide polymorphisms (SNPs) that are associated with the pathogenesis of Alzheimer’s disease (AD). As replication in independent studies remains the only way to validate proposed GWAS signals, we detect SNPs reported in the GWAS,...