Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature

• Published in: Scientific reports Vol. 5; no. 1; p. 16429
• Main Authors: Ng, Tsz Kin, Yung, Jasmine S. Y., Choy, Kwong Wai, Cao, Di, Leung, Christopher K. S., Cheung, Herman S., Pang, Chi Pui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.11.2015; Nature Publishing Group
• Subjects: 13/100; 14/35; 14/63; 38/61; 631/337/384/331; 631/532/1360; Beta2 protein; Biomarkers; Blindness; Calcium; Calcium Signaling - drug effects; Cell Transdifferentiation; Cells, Cultured; Cluster Analysis; Computational Biology - methods; Developed countries; Gene Expression Profiling; Glutamic Acid - pharmacology; Humanities and Social Sciences; Humans; MicroRNAs; MicroRNAs - genetics; miRNA; multidisciplinary; Periodontal ligament; Periodontal Ligament - cytology; PTEN protein; Retina; Retinal Ganglion Cells - cytology; Retinal Ganglion Cells - metabolism; RNA Interference; RNA, Messenger - genetics; Science; Six3 gene; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Tau protein; Transcriptome; Tubulin; Vascular endothelial growth factor

Retinal diseases are the leading causes of irreversible visual impairment and blindness in the developed countries. Human retina has limited regenerative power to replace cell loss. Stem cell replacement therapy has been proposed as a viable option. Previously, we have induced human adult periodonta...