Mutational and biochemical analysis of cytochrome c', a nitric oxide-binding lipoprotein important for adaptation of Neisseria gonorrhoeae to oxygen-limited growth
Neisseria gonorrhoeae is a prolific source of c-type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis of the N. gonorrhoeae genome, to be components of the cytochrome bc1 complex, cytochrome c oxidase cbb3 or periplasmic cytochromes involved in...
Saved in:
Published in | Biochemical journal Vol. 388; no. Pt 2; pp. 545 - 553 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Portland Press Ltd
01.06.2005
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Neisseria gonorrhoeae is a prolific source of c-type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis of the N. gonorrhoeae genome, to be components of the cytochrome bc1 complex, cytochrome c oxidase cbb3 or periplasmic cytochromes involved in electron transfer reactions typical of a bacterium with a microaerobic physiology. Cytochrome c peroxidase was previously shown to be a lipoprotein expressed only during oxygen-limited growth. The final c-type cytochrome, cytochrome c', similar to cytochrome c peroxidase, includes a lipobox required for targeting to the outer membrane. Maturation of cytochrome c' was partially inhibited by globomycin, an antibiotic that specifically inhibits signal peptidase II, resulting in the accumulation of the prolipoprotein in the cytoplasmic membrane. Disruption of the gonococcal cycP gene resulted in an extended lag phase during microaerobic growth in the presence but not in the absence of nitrite, suggesting that cytochrome c' protects the bacteria from NO generated by nitrite reduction during adaptation to oxygen-limited growth. The cytochrome c' gene was overexpressed in Escherichia coli and recombinant cytochrome c' was shown to be targeted to the outer membrane. Spectroscopic evidence is presented showing that gonococcal cytochrome c' is similar to previously characterized cytochrome c' proteins and that it binds NO in vitro. The demonstration that two of the seven gonococcal c-type cytochromes fulfil specialized functions and are outer membrane lipoproteins suggests that the localization of these lipoproteins close to the bacterial surface provides effective protection against external assaults from reactive oxygen and reactive nitrogen species. |
---|---|
AbstractList | Neisseria gonorrhoeae is a prolific source of c-type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis of the N. gonorrhoeae genome, to be components of the cytochrome bc sub(1) complex, cytochrome c oxidase cbb sub(3) or periplasmic cytochromes involved in electron transfer reactions typical of a bacterium with a microaerobic physiology. Cytochrome c peroxidase was previously shown to be a lipoprotein expressed only during oxygen-limited growth. The final c-type cytochrome, cytochrome c', similar to cytochrome c peroxidase, includes a lipobox required for targeting to the outer membrane. Maturation of cytochrome c' was partially inhibited by globomycin, an antibiotic that specifically inhibits signal peptidase II, resulting in the accumulation of the prolipoprotein in the cytoplasmic membrane. Disruption of the gonococcal cycP gene resulted in an extended lag phase during microaerobic growth in the presence but not in the absence of nitrite, suggesting that cytochrome c' protects the bacteria from NO generated by nitrite reduction during adaptation to oxygen-limited growth. The cytochrome c' gene was overexpressed in Escherichia coli and recombinant cytochrome c' was shown to be targeted to the outer membrane. Spectroscopic evidence is presented showing that gonococcal cytochrome c' is similar to previously characterized cytochrome c' proteins and that it binds NO in vitro. The demonstration that two of the seven gonococcal c-type cytochromes fulfil specialized functions and are outer membrane lipoproteins suggests that the localization of these lipoproteins close to the bacterial surface provides effective protection against external assaults from reactive oxygen and reactive nitrogen species. Neisseria gonorrhoeae is a prolific source of c-type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis of the N. gonorrhoeae genome, to be components of the cytochrome bc1 complex, cytochrome c oxidase cbb3 or periplasmic cytochromes involved in electron transfer reactions typical of a bacterium with a microaerobic physiology. Cytochrome c peroxidase was previously shown to be a lipoprotein expressed only during oxygen-limited growth. The final c-type cytochrome, cytochrome c′, similar to cytochrome c peroxidase, includes a lipobox required for targeting to the outer membrane. Maturation of cytochrome c′ was partially inhibited by globomycin, an antibiotic that specifically inhibits signal peptidase II, resulting in the accumulation of the prolipoprotein in the cytoplasmic membrane. Disruption of the gonococcal cycP gene resulted in an extended lag phase during microaerobic growth in the presence but not in the absence of nitrite, suggesting that cytochrome c′ protects the bacteria from NO generated by nitrite reduction during adaptation to oxygen-limited growth. The cytochrome c′ gene was overexpressed in Escherichia coli and recombinant cytochrome c′ was shown to be targeted to the outer membrane. Spectroscopic evidence is presented showing that gonococcal cytochrome c′ is similar to previously characterized cytochrome c′ proteins and that it binds NO in vitro. The demonstration that two of the seven gonococcal c-type cytochromes fulfil specialized functions and are outer membrane lipoproteins suggests that the localization of these lipoproteins close to the bacterial surface provides effective protection against external assaults from reactive oxygen and reactive nitrogen species. Neisseria gonorrhoeae is a prolific source of c -type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis of the N. gonorrhoeae genome, to be components of the cytochrome bc 1 complex, cytochrome c oxidase cbb 3 or periplasmic cytochromes involved in electron transfer reactions typical of a bacterium with a microaerobic physiology. Cytochrome c peroxidase was previously shown to be a lipoprotein expressed only during oxygen-limited growth. The final c -type cytochrome, cytochrome c ′, similar to cytochrome c peroxidase, includes a lipobox required for targeting to the outer membrane. Maturation of cytochrome c ′ was partially inhibited by globomycin, an antibiotic that specifically inhibits signal peptidase II, resulting in the accumulation of the prolipoprotein in the cytoplasmic membrane. Disruption of the gonococcal cycP gene resulted in an extended lag phase during microaerobic growth in the presence but not in the absence of nitrite, suggesting that cytochrome c ′ protects the bacteria from NO generated by nitrite reduction during adaptation to oxygen-limited growth. The cytochrome c ′ gene was overexpressed in Escherichia coli and recombinant cytochrome c ′ was shown to be targeted to the outer membrane. Spectroscopic evidence is presented showing that gonococcal cytochrome c ′ is similar to previously characterized cytochrome c ′ proteins and that it binds NO in vitro . The demonstration that two of the seven gonococcal c -type cytochromes fulfil specialized functions and are outer membrane lipoproteins suggests that the localization of these lipoproteins close to the bacterial surface provides effective protection against external assaults from reactive oxygen and reactive nitrogen species. |
Author | Moir, James W B Cole, Jeff A Overton, Timothy W Griffiths, Lesley Turner, Susan M Smith, Harry |
Author_xml | – sequence: 1 givenname: Susan M surname: Turner fullname: Turner, Susan M organization: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK – sequence: 2 givenname: James W B surname: Moir fullname: Moir, James W B – sequence: 3 givenname: Lesley surname: Griffiths fullname: Griffiths, Lesley – sequence: 4 givenname: Timothy W surname: Overton fullname: Overton, Timothy W – sequence: 5 givenname: Harry surname: Smith fullname: Smith, Harry – sequence: 6 givenname: Jeff A surname: Cole fullname: Cole, Jeff A |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15689189$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkc1u1DAURi1URKeFDQ-AvAIJEfC1ncTZIEHFrwpsYB05zk3mosRObQ8wz8OLkjIjCivkhWV9R-de-TtjJz54ZOw-iKcgtHz28r0UQkNdVbfYBnQtClNLc8I2Qla6qISEU3aW0lchQAst7rBTKCvTgGk27OeHXbaZgrcTt77nHQW3xZnc77ed9okSDwN3-7wGMczI3aMn3HJPOZLj4Qf1WHTke_Ijn2gJSwwZyXOalxCz9ZkPIXLb2-Uw6Nr2ESkljGT5GHyIcRvQIs9h1e1H9MVEM2Xs-RjD97y9y24Pdkp473ifsy-vX32-eFtcfnrz7uLFZeG0Mrnowbq-cQh6UFqWFvR6QNVrKIV2TaclgjJC9rUCgWBw_ZoSelVBpzuh1Dl7fvAuu27G3qHP0U7tEmm2cd8GS-2_iadtO4Zv7TrFNJVcBQ-PghiudphyO1NyOE3WY9ilFprKaFHp_4O1MiWUZgUfH0AXQ0oRhz_bgGivy29vyl_hB3_vf4Me21a_AHzbryM |
CitedBy_id | crossref_primary_10_1074_mcp_M116_058800 crossref_primary_10_1128_AEM_00463_06 crossref_primary_10_1128_IAI_06163_11 crossref_primary_10_1371_journal_pone_0077302 crossref_primary_10_1007_s10534_006_9059_2 crossref_primary_10_1099_mic_0_059048_0 crossref_primary_10_1371_journal_pone_0187900 crossref_primary_10_1128_JB_00002_10 crossref_primary_10_1099_mic_0_2008_020339_0 crossref_primary_10_1128_JB_00080_07 crossref_primary_10_1099_mic_0_28126_0 crossref_primary_10_1128_AAC_00186_17 crossref_primary_10_1099_mic_0_028092_0 crossref_primary_10_1128_JB_01869_07 crossref_primary_10_1016_j_jsb_2023_108031 crossref_primary_10_1042_BST20110736 crossref_primary_10_1128_JB_02300_12 crossref_primary_10_1021_ja209770p crossref_primary_10_1128_MMBR_00044_05 crossref_primary_10_1186_s13568_019_0888_0 crossref_primary_10_1371_journal_pone_0013680 crossref_primary_10_1016_j_ceb_2009_09_009 crossref_primary_10_1016_j_jinorgbio_2024_112496 |
Cites_doi | 10.1016/S0014-5793(03)00632-X 10.1093/clinids/8.1.86 10.1016/S0021-9258(19)85762-9 10.1128/jb.178.6.1532-1538.1996 10.1128/jb.173.7.2147-2154.1991 10.1016/0003-2697(76)90320-1 10.1128/jb.166.3.1072-1082.1986 10.1128/JB.183.10.3050-3054.2001 10.7164/antibiotics.31.410 10.1006/abbi.1995.1044 10.1093/emboj/16.23.6947 10.1128/JB.182.5.1442-1447.2000 10.1038/35008635 10.1016/0003-9861(92)90433-W 10.1016/S0021-9258(17)32077-X 10.1016/S0167-4838(98)00276-3 10.1016/0882-4010(88)90038-1 10.1128/JB.184.11.2987-2993.2002 10.1046/j.1365-2958.2000.02050.x 10.1093/emboj/19.21.5661 10.1099/00221287-95-2-353 10.1016/0006-291X(87)91045-X 10.1128/JB.184.5.1417-1422.2002 10.1016/0167-4838(95)00187-5 10.1016/S0021-9258(18)88911-6 10.1172/JCI115912 10.1016/S0005-2728(05)80274-9 10.1046/j.1365-2958.1999.01647.x 10.1002/j.1460-2075.1995.tb07342.x 10.1128/iai.46.1.176-181.1984 10.1016/0092-8674(88)90162-6 10.3181/00379727-145-38025 10.1128/iai.55.6.1359-1364.1987 10.1128/mr.57.1.50-108.1993 10.1016/0003-2697(76)90067-1 10.1099/00221287-96-2-341 10.1042/bj20030088 10.1007/s004380050597 10.1128/IAI.68.7.4368-4369.2000 10.1126/science.287.5459.1809 10.1128/IAI.68.9.5241-5246.2000 10.1084/jem.192.2.227 10.1016/0003-9861(92)90434-X 10.1074/jbc.M109307200 10.1007/BF00410732 10.1016/S0021-9258(19)52451-6 10.1074/jbc.M307836200 10.1073/pnas.79.7.2255 10.1016/S0021-9258(17)43305-9 10.1038/35006655 |
ContentType | Journal Article |
Copyright | The Biochemical Society, London 2005 |
Copyright_xml | – notice: The Biochemical Society, London 2005 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7QO 8FD C1K FR3 P64 5PM |
DOI | 10.1042/BJ20041766 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Engineering Research Database Biotechnology Research Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
DatabaseTitleList | Engineering Research Database CrossRef Engineering Research Database MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry |
DocumentTitleAlternate | Cytochrome c′, an NO-binding lipoprotein in gonococci |
EISSN | 1470-8728 |
EndPage | 553 |
ExternalDocumentID | 10_1042_BJ20041766 15689189 |
Genre | Research Support, U.S. Gov't, P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NIAID NIH HHS grantid: AI38399 |
GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 23N 2WC 3EH 3O- 4.4 53G 5GY 5RE 5VS 6J9 79B AABGO AAHRG ABPPZ ABTAH ACGFO ACGFS ACNCT ADBBV AEGXH AENEX AI. AIAGR AIZAD ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DU5 E3Z EBS ECM EIF EJD F20 F5P H13 HH6 HYE HZ~ K-O L7B MV1 MVM N9A NPM O9- OHT OK1 P2P RHI RNS RPM RPO TR2 TWZ VH1 WH7 WOQ X7M XOL XSW Y6R YNY ZXP ZY4 ~02 ~KM AAYXX CITATION 7QL 7QO 8FD C1K FR3 P64 5PM |
ID | FETCH-LOGICAL-c438t-d1acd9ce14f3425a14141137438204c9b42e13802d7310e18e60251d361b4b033 |
IEDL.DBID | RPM |
ISSN | 0264-6021 |
IngestDate | Tue Sep 17 20:48:04 EDT 2024 Sun Sep 29 07:47:19 EDT 2024 Fri Aug 16 12:00:49 EDT 2024 Fri Aug 23 01:25:33 EDT 2024 Sat Sep 28 07:51:42 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | Pt 2 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c438t-d1acd9ce14f3425a14141137438204c9b42e13802d7310e18e60251d361b4b033 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://europepmc.org/articles/pmc1138962?pdf=render |
PMID | 15689189 |
PQID | 17385158 |
PQPubID | 23462 |
PageCount | 9 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_1138962 proquest_miscellaneous_19684064 proquest_miscellaneous_17385158 crossref_primary_10_1042_BJ20041766 pubmed_primary_15689189 |
PublicationCentury | 2000 |
PublicationDate | 2005-06-01 |
PublicationDateYYYYMMDD | 2005-06-01 |
PublicationDate_xml | – month: 06 year: 2005 text: 2005-06-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Biochemical journal |
PublicationTitleAlternate | Biochem J |
PublicationYear | 2005 |
Publisher | Portland Press Ltd |
Publisher_xml | – name: Portland Press Ltd |
References | 8096622 - Microbiol Rev. 1993 Mar;57(1):50-108 11060017 - EMBO J. 2000 Nov 1;19(21):5661-71 1416976 - Arch Biochem Biophys. 1992 Nov 1;298(2):452-7 1646026 - Biochim Biophys Acta. 1991 May 23;1058(1):79-82 8051048 - J Biol Chem. 1994 Aug 5;269(31):19701-6 786067 - Anal Biochem. 1976 Jul;74(1):160-70 6321507 - J Biol Chem. 1984 Mar 10;259(5):3375-81 14907713 - J Biol Chem. 1951 Nov;193(1):265-75 4208046 - Proc Soc Exp Biol Med. 1974 Apr;145(4):1418-21 10082934 - Biochim Biophys Acta. 1999 Feb 10;1430(1):65-72 10972806 - Mol Microbiol. 2000 Aug;37(4):839-55 3519574 - J Bacteriol. 1986 Jun;166(3):1072-82 10948150 - Infect Immun. 2000 Sep;68(9):5241-6 1522209 - J Clin Invest. 1992 Sep;90(3):1000-6 11592971 - J Biol Chem. 2001 Dec 14;276(50):47690-4 822747 - Anal Biochem. 1976 Sep;75(1):168-76 10761919 - Nature. 2000 Mar 30;404(6777):502-6 11844772 - J Bacteriol. 2002 Mar;184(5):1417-22 12720546 - Biochem J. 2003 Aug 1;373(Pt 3):865-73 825610 - J Gen Microbiol. 1976 Oct;96(2):341-50 10899909 - J Exp Med. 2000 Jul 17;192(2):227-36 7628437 - EMBO J. 1995 Jul 17;14(14):3365-72 2937130 - Rev Infect Dis. 1986 Jan-Feb;8(1):86-116 9384574 - EMBO J. 1997 Dec 1;16(23):6947-55 10671472 - J Bacteriol. 2000 Mar;182(5):1442-7 3148817 - Microb Pathog. 1988 Nov;5(5):381-90 1848839 - J Bacteriol. 1991 Apr;173(7):2147-54 7840633 - Arch Biochem Biophys. 1995 Jan 10;316(1):327-34 9413436 - Mol Gen Genet. 1997 Nov;256(5):525-32 10858263 - Infect Immun. 2000 Jul;68(7):4368-9 10564520 - Mol Microbiol. 1999 Nov;34(4):810-21 11325932 - J Bacteriol. 2001 May;183(10):3050-4 7048314 - Proc Natl Acad Sci U S A. 1982 Apr;79(7):2255-9 8547347 - Biochim Biophys Acta. 1996 Jan 4;1292(1):39-46 670084 - J Antibiot (Tokyo). 1978 May;31(5):410-20 3888977 - J Biol Chem. 1985 May 25;260(10):5891-4 12832079 - FEBS Lett. 2003 Jul 10;546(2-3):411-5 6988430 - J Biol Chem. 1980 Apr 25;255(8):3707-12 6434425 - Infect Immun. 1984 Oct;46(1):176-81 8626278 - J Bacteriol. 1996 Mar;178(6):1532-8 12896969 - J Biol Chem. 2003 Oct 10;278(41):40408-14 3036144 - Biochem Biophys Res Commun. 1987 Jun 15;145(2):868-75 3284654 - Cell. 1988 May 6;53(3):423-32 3106220 - Infect Immun. 1987 Jun;55(6):1359-64 822128 - J Gen Microbiol. 1976 Aug;96(2):353-63 1329657 - Arch Biochem Biophys. 1992 Nov 1;298(2):446-51 10710307 - Science. 2000 Mar 10;287(5459):1809-15 12003939 - J Bacteriol. 2002 Jun;184(11):2987-93 10783239 - Nat Cell Biol. 2000 Apr;2(4):212-8 Moir (2021112217433690800_B35) 1999; 1430 Yoshimura (2021112217433690800_B33) 1987; 145 Yakushi (2021112217433690800_B43) 2000; 2 Cross (2021112217433690800_B50) 2000; 182 Lissenden (2021112217433690800_B8) 2000; 37 Vazquez-Torres (2021112217433690800_B1) 2000; 192 Matsuyama (2021112217433690800_B42) 1997; 16 Turner (2021112217433690800_B9) 2003; 373 Clark (2021112217433690800_B14) 1988; 5 Burnakis (2021112217433690800_B16) 1986; 8 Hara (2021112217433690800_B47) 2003; 278 Witt (2021112217433690800_B6) 1976; 96 Mellies (2021112217433690800_B12) 1997; 256 Parkhill (2021112217433690800_B26) 2000; 404 Narita (2021112217433690800_B44) 2002; 184 Seib (2021112217433690800_B19) 2003; 546 Strange (2021112217433690800_B7) 1994 Thomas (2021112217433690800_B25) 1976; 75 Tokunaga (2021112217433690800_B39) 1982; 79 Veale (2021112217433690800_B5) 1976; 95 Iwasaki (2021112217433690800_B32) 1991; 1058 Hussain (2021112217433690800_B30) 1980; 255 Householder (2021112217433690800_B18) 2000; 68 Anjum (2021112217433690800_B20) 2002; 184 Preisig (2021112217433690800_B38) 1996; 178 Zheng (2021112217433690800_B17) 1992; 90 Zhu (2021112217433690800_B3) 1992; 298 Witholt (2021112217433690800_B22) 1976; 74 Knapp (2021112217433690800_B11) 1984; 46 Nassif (2021112217433690800_B52) 1991; 173 Cardinale (2021112217433690800_B13) 2000; 68 Terada (2021112217433690800_B46) 2001; 276 Kita (2021112217433690800_B37) 1984; 259 Matsuyama (2021112217433690800_B41) 1995; 14 Clark (2021112217433690800_B49) 1987; 55 Morse (2021112217433690800_B10) 1974; 145 Doherty (2021112217433690800_B23) 1986; 166 McEwan (2021112217433690800_B21) 1984; 137 Smith (2021112217433690800_B15) 1975 Lowry (2021112217433690800_B24) 1951; 193 Seydel (2021112217433690800_B45) 1999; 34 Sankaran (2021112217433690800_B28) 1994; 269 Cross (2021112217433690800_B51) 2001; 183 Yoshimura (2021112217433690800_B34) 1996; 1292 Lawson (2021112217433690800_B36) 2000; 19 Dev (2021112217433690800_B31) 1985; 260 Yamaguchi (2021112217433690800_B44a) 1988; 53 Ischiropoulos (2021112217433690800_B2) 1992; 298 Brunelli (2021112217433690800_B4) 1995; 316 Narita (2021112217433690800_B48) 2002; 184 Tettelin (2021112217433690800_B27) 2000; 287 Pugsley (2021112217433690800_B40) 1993; 57 Inukai (2021112217433690800_B29) 1978; 31 |
References_xml | – volume: 546 start-page: 411 year: 2003 ident: 2021112217433690800_B19 article-title: A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria publication-title: FEBS Lett. doi: 10.1016/S0014-5793(03)00632-X contributor: fullname: Seib – volume: 8 start-page: 86 year: 1986 ident: 2021112217433690800_B16 article-title: Pelvic inflammatory disease: a review with emphasis on antimicrobial therapy publication-title: Rev. Infect. Dis. doi: 10.1093/clinids/8.1.86 contributor: fullname: Burnakis – volume: 255 start-page: 3707 year: 1980 ident: 2021112217433690800_B30 article-title: Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)85762-9 contributor: fullname: Hussain – volume: 178 start-page: 1532 year: 1996 ident: 2021112217433690800_B38 article-title: A high-affinity cbb3-type cytochrome oxidase terminates the symbiosis-specific respiratory chain of Bradyrhizobium japonicum publication-title: J. Bacteriol. doi: 10.1128/jb.178.6.1532-1538.1996 contributor: fullname: Preisig – volume: 173 start-page: 2147 year: 1991 ident: 2021112217433690800_B52 article-title: Transposition of Tn1545-Δ3 in the pathogenic neisseria: a genetic tool for mutagenesis publication-title: J. Bacteriol. doi: 10.1128/jb.173.7.2147-2154.1991 contributor: fullname: Nassif – volume: 74 start-page: 160 year: 1976 ident: 2021112217433690800_B22 article-title: An efficient and reproducible procedure for the formation of spheroplasts from variously grown Escherichia coli publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90320-1 contributor: fullname: Witholt – volume: 166 start-page: 1072 year: 1986 ident: 2021112217433690800_B23 article-title: Identification, immunochemical characterization, and purification of a major lipoprotein antigen associated with the inner (cytoplasmic) membrane of Escherichia coli publication-title: J. Bacteriol. doi: 10.1128/jb.166.3.1072-1082.1986 contributor: fullname: Doherty – volume: 183 start-page: 3050 year: 2001 ident: 2021112217433690800_B51 article-title: Enzymatic removal of nitric oxide catalyzed by cytochrome c′ in Rhodobacter capsulatus publication-title: J. Bacteriol. doi: 10.1128/JB.183.10.3050-3054.2001 contributor: fullname: Cross – volume: 31 start-page: 410 year: 1978 ident: 2021112217433690800_B29 article-title: Globomycin, a new peptide antibiotic with spheroplast-forming activity. I. Taxonomy of producing organisms and fermentation publication-title: J. Antibiot. doi: 10.7164/antibiotics.31.410 contributor: fullname: Inukai – volume: 316 start-page: 327 year: 1995 ident: 2021112217433690800_B4 article-title: The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli publication-title: Arch. Biochem. Biophys. doi: 10.1006/abbi.1995.1044 contributor: fullname: Brunelli – volume: 16 start-page: 6947 year: 1997 ident: 2021112217433690800_B42 article-title: A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli publication-title: EMBO J. doi: 10.1093/emboj/16.23.6947 contributor: fullname: Matsuyama – volume: 182 start-page: 1442 year: 2000 ident: 2021112217433690800_B50 article-title: Cytochrome c′ from Rhodobacter capsulatus confers increased resistance to nitric oxide publication-title: J. Bacteriol. doi: 10.1128/JB.182.5.1442-1447.2000 contributor: fullname: Cross – start-page: 417 volume-title: Pathobiology and Immunobiology of Neisseriaceae, Proceedings of the Eighth Pathogenic Neisseria Conference held at Mexico City year: 1994 ident: 2021112217433690800_B7 article-title: Identification of heme-containing proteins of Neisseria gonorrhoeae contributor: fullname: Strange – volume: 2 start-page: 212 year: 2000 ident: 2021112217433690800_B43 article-title: A new ABC transporter mediating the detachment of lipid-modified proteins from membranes publication-title: Nat. Cell Biol. doi: 10.1038/35008635 contributor: fullname: Yakushi – volume: 298 start-page: 446 year: 1992 ident: 2021112217433690800_B2 article-title: Peroxynitrite formation from macrophage-derived nitric oxide publication-title: Arch. Biochem. Biophys. doi: 10.1016/0003-9861(92)90433-W contributor: fullname: Ischiropoulos – volume: 269 start-page: 19701 year: 1994 ident: 2021112217433690800_B28 article-title: Lipid modification of bacterial prolipoprotein publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)32077-X contributor: fullname: Sankaran – volume: 1430 start-page: 65 year: 1999 ident: 2021112217433690800_B35 article-title: Cytochrome c′ from Paracoccus denitrificans: spectroscopic studies consistent with a role for the protein in nitric oxide metabolism publication-title: Biochim. Biophys. Acta doi: 10.1016/S0167-4838(98)00276-3 contributor: fullname: Moir – volume: 5 start-page: 381 year: 1988 ident: 2021112217433690800_B14 article-title: Presence of antibodies to the major anaerobically induced gonococcal outer membrane protein in sera from patients with gonococcal infections publication-title: Microb. Pathog. doi: 10.1016/0882-4010(88)90038-1 contributor: fullname: Clark – volume: 184 start-page: 2987 year: 2002 ident: 2021112217433690800_B20 article-title: Nitric oxide metabolism in Neisseria meningitidis publication-title: J. Bacteriol. doi: 10.1128/JB.184.11.2987-2993.2002 contributor: fullname: Anjum – year: 1975 ident: 2021112217433690800_B15 article-title: The Pathogenic Anaerobic Bacteria contributor: fullname: Smith – volume: 37 start-page: 839 year: 2000 ident: 2021112217433690800_B8 article-title: Identification of transcription activators which regulate gonococcal adaption from aerobic to anaerobic or oxygen-limited growth publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.2000.02050.x contributor: fullname: Lissenden – volume: 19 start-page: 5661 year: 2000 ident: 2021112217433690800_B36 article-title: Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase publication-title: EMBO J. doi: 10.1093/emboj/19.21.5661 contributor: fullname: Lawson – volume: 95 start-page: 353 year: 1976 ident: 2021112217433690800_B5 article-title: Penetration of penicillin into human phagocytes containing Neisseria gonorrhoeae: intracellular survival and growth at optimum concentrations of antibiotic publication-title: J. Gen. Microbiol. doi: 10.1099/00221287-95-2-353 contributor: fullname: Veale – volume: 145 start-page: 868 year: 1987 ident: 2021112217433690800_B33 article-title: Spectral properties of nitric oxide complex of cytochrome c′ from Rhodopseudomonas capsulata B100 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(87)91045-X contributor: fullname: Yoshimura – volume: 184 start-page: 1417 year: 2002 ident: 2021112217433690800_B48 article-title: Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane publication-title: J. Bacteriol. doi: 10.1128/JB.184.5.1417-1422.2002 contributor: fullname: Narita – volume: 1292 start-page: 39 year: 1996 ident: 2021112217433690800_B34 article-title: Spectroscopic characterization of nitrosylheme in nitric oxide complexes of ferric and ferrous cytochrome c′ from photosynthetic bacteria publication-title: Biochim. Biophys. Acta doi: 10.1016/0167-4838(95)00187-5 contributor: fullname: Yoshimura – volume: 260 start-page: 5891 year: 1985 ident: 2021112217433690800_B31 article-title: Inhibition of proplipoprotein signal peptidase by globomycin publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)88911-6 contributor: fullname: Dev – volume: 90 start-page: 1000 year: 1992 ident: 2021112217433690800_B17 article-title: Regulation of catalase in Neisseria gonorrhoeae publication-title: J. Clin. Invest. doi: 10.1172/JCI115912 contributor: fullname: Zheng – volume: 1058 start-page: 79 year: 1991 ident: 2021112217433690800_B32 article-title: Spectral properties of Achromobacter xylosoxidans cytochromes c′ and their NO complexes publication-title: Biochim. Biophys. Acta doi: 10.1016/S0005-2728(05)80274-9 contributor: fullname: Iwasaki – volume: 34 start-page: 810 year: 1999 ident: 2021112217433690800_B45 article-title: Testing the ‘+2 rule’ for lipoprotein sorting in the Escherichia coli cell envelope with a new genetic selection publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.1999.01647.x contributor: fullname: Seydel – volume: 14 start-page: 3365 year: 1995 ident: 2021112217433690800_B41 article-title: A novel periplasmic carrier protein involved in the sorting and transport of Escherichia coli lipoproteins destined for the outer membrane publication-title: EMBO J. doi: 10.1002/j.1460-2075.1995.tb07342.x contributor: fullname: Matsuyama – volume: 46 start-page: 176 year: 1984 ident: 2021112217433690800_B11 article-title: Anaerobic growth of Neisseria gonorrhoeae coupled to nitrite reduction publication-title: Infect. Immun. doi: 10.1128/iai.46.1.176-181.1984 contributor: fullname: Knapp – volume: 53 start-page: 423 year: 1988 ident: 2021112217433690800_B44a article-title: A single amino acid determinant of the membrane localisation of lipoproteins in E. coli publication-title: Cell (Cambridge, Mass.) doi: 10.1016/0092-8674(88)90162-6 contributor: fullname: Yamaguchi – volume: 145 start-page: 1418 year: 1974 ident: 2021112217433690800_B10 article-title: Factors affecting autolysis of Neisseria gonorrhoeae publication-title: Proc. Soc. Exp. Biol. Med. doi: 10.3181/00379727-145-38025 contributor: fullname: Morse – volume: 184 start-page: 1417 year: 2002 ident: 2021112217433690800_B44 article-title: Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane publication-title: J. Bacteriol. doi: 10.1128/JB.184.5.1417-1422.2002 contributor: fullname: Narita – volume: 55 start-page: 1359 year: 1987 ident: 2021112217433690800_B49 article-title: Induction and repression of outer membrane proteins by anaerobic growth of Neisseria gonorrhoeae publication-title: Infect. Immun. doi: 10.1128/iai.55.6.1359-1364.1987 contributor: fullname: Clark – volume: 57 start-page: 50 year: 1993 ident: 2021112217433690800_B40 article-title: The complete general secretory pathway in Gram-negative bacteria publication-title: Microbiol. Rev. doi: 10.1128/mr.57.1.50-108.1993 contributor: fullname: Pugsley – volume: 75 start-page: 168 year: 1976 ident: 2021112217433690800_B25 article-title: An improved staining procedure for the detection of peroxidase activity of cytochrome P-450 on sodium dodecyl sulphate polyacrylamide gels publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90067-1 contributor: fullname: Thomas – volume: 96 start-page: 341 year: 1976 ident: 2021112217433690800_B6 article-title: Resistance of Neisseria gonorrhoeae grown in vivo to ingestion and digestion by phagocytes of human blood publication-title: J. Gen. Microbiol. doi: 10.1099/00221287-96-2-341 contributor: fullname: Witt – volume: 373 start-page: 865 year: 2003 ident: 2021112217433690800_B9 article-title: A novel cytochrome c peroxidase from Neisseria gonorrhoeae: a lipoprotein from a Gram-negative bacterium publication-title: Biochem. J. doi: 10.1042/bj20030088 contributor: fullname: Turner – volume: 256 start-page: 532 year: 1997 ident: 2021112217433690800_B12 article-title: The Neisseria gonorrhoeae gene aniA encodes an inducible nitrite reductase publication-title: Mol. Gen. Genet. doi: 10.1007/s004380050597 contributor: fullname: Mellies – volume: 68 start-page: 4368 year: 2000 ident: 2021112217433690800_B13 article-title: Expression of AniA, the major anaerobically induced outer membrane protein of Neisseria gonorrhoeae, provides protection against killing by normal human sera publication-title: Infect. Immun. doi: 10.1128/IAI.68.7.4368-4369.2000 contributor: fullname: Cardinale – volume: 287 start-page: 1809 year: 2000 ident: 2021112217433690800_B27 article-title: Complete genome sequence of Neisseria meningitidis publication-title: Science doi: 10.1126/science.287.5459.1809 contributor: fullname: Tettelin – volume: 68 start-page: 5241 year: 2000 ident: 2021112217433690800_B18 article-title: Gonococcal nitric oxide reductase is encoded by a single gene, norB, which is required for anaerobic growth and is induced by nitric oxide publication-title: Infect. Immun. doi: 10.1128/IAI.68.9.5241-5246.2000 contributor: fullname: Householder – volume: 192 start-page: 227 year: 2000 ident: 2021112217433690800_B1 article-title: Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro publication-title: J. Exp. Med. doi: 10.1084/jem.192.2.227 contributor: fullname: Vazquez-Torres – volume: 298 start-page: 452 year: 1992 ident: 2021112217433690800_B3 article-title: Bactericidal activity of peroxynitrite publication-title: Arch. Biochem. Biophys. doi: 10.1016/0003-9861(92)90434-X contributor: fullname: Zhu – volume: 276 start-page: 47690 year: 2001 ident: 2021112217433690800_B46 article-title: Lipoprotein sorting signals evaluated as the LolA-dependent release of lipoproteins from the cytoplasmic membrane of Escherichia coli publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109307200 contributor: fullname: Terada – volume: 137 start-page: 344 year: 1984 ident: 2021112217433690800_B21 article-title: Rationalization of properties of nitrate reductases in Rhodopseudomonas capsulata publication-title: Arch. Microbiol. doi: 10.1007/BF00410732 contributor: fullname: McEwan – volume: 193 start-page: 265 year: 1951 ident: 2021112217433690800_B24 article-title: Protein measurement with the Folin phenol reagent publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)52451-6 contributor: fullname: Lowry – volume: 278 start-page: 40408 year: 2003 ident: 2021112217433690800_B47 article-title: Mechanism underlying the inner membrane retention of Escherichia coli lipoproteins caused by Lol avoidance signals publication-title: J. Biol. Chem. doi: 10.1074/jbc.M307836200 contributor: fullname: Hara – volume: 79 start-page: 2255 year: 1982 ident: 2021112217433690800_B39 article-title: Post-translational modification and processing of Escherichia coli pro-lipoprotein in vitro publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.79.7.2255 contributor: fullname: Tokunaga – volume: 259 start-page: 3375 year: 1984 ident: 2021112217433690800_B37 article-title: Terminal oxidases of Escherichia coli aerobic respiratory chain publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)43305-9 contributor: fullname: Kita – volume: 404 start-page: 502 year: 2000 ident: 2021112217433690800_B26 article-title: Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491 publication-title: Nature (London) doi: 10.1038/35006655 contributor: fullname: Parkhill |
SSID | ssj0014040 |
Score | 2.0061607 |
Snippet | Neisseria gonorrhoeae is a prolific source of c-type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis... Neisseria gonorrhoeae is a prolific source of c -type cytochromes. Five of the constitutively expressed cytochromes are predicted, based on in silico analysis... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 545 |
SubjectTerms | Adaptation, Physiological Cytochromes c' - chemistry Cytochromes c' - metabolism Escherichia coli Escherichia coli - genetics Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Lipoproteins - chemistry Mutagenesis, Site-Directed Neisseria gonorrhoeae Neisseria gonorrhoeae - enzymology Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - growth & development Nitric Oxide - metabolism Nitrites - metabolism Oxygen - physiology Phenotype Protein Binding Protein Processing, Post-Translational |
Title | Mutational and biochemical analysis of cytochrome c', a nitric oxide-binding lipoprotein important for adaptation of Neisseria gonorrhoeae to oxygen-limited growth |
URI | https://www.ncbi.nlm.nih.gov/pubmed/15689189 https://search.proquest.com/docview/17385158 https://search.proquest.com/docview/19684064 https://pubmed.ncbi.nlm.nih.gov/PMC1138962 |
Volume | 388 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbaXuCCaMtjaYGRQJxIN46d17GsqKpKW3GgUm-RX-lG2rVXS1Z0b_0z_QP8JH4JYyehLUgcUE6RnXGUGWee_oaQ92WRKcYEi-I8ZxHXtIwE6tUor1EXmFzlrPahgel5dnrBzy7Tyy2SDmdhQtG-ks2RnS-ObDMLtZXLhRoPdWLjL9MJ9dm1LBlvk-2cscFF71MHPOZ9YIVHGWqwAZOUJ-NPZ14mPCRi6MaTFSX17d3vK6S_rMw_iyXvaZ-Tp-RJbzbCcfd6u2TL2D2yf2zRZV5s4AOEQs4QId8jjyZDE7d9cjtdt324D4TVIBvfIStABOB9h0cCrga1aXHAQxeA-nnz4yMIwL2O_0hw14023n_2Sg7mzdIFaIfGQrMItrttAQ1fEFosu6U8vXMT8vyNgCtn3Wo1c0YYaB2S26DIRvPuXBVcrdz3dvaMXJx8_jo5jfrODJHirGgjTYXSpTKU1ww3vaAcL8pyn1WMuSolTwzyKE50juajoYXJvC-jWUYllzFjz8mOdda8JBALQ6lkSC4WPDWpYDWVGg3B2sPCUDki7wb2VMsOgKMKiXOeVHf8HJG3A-cq_MI-6SGscetvFfVwPTQt_jGj9IA3GR-RFx2n79bpRWRE8gcy8HuCx-Z-OIIiGzC6exF99d9PHpDHASU2BHwOyU67WpvXaP-08k2Q91_FAwkR |
link.rule.ids | 230,315,733,786,790,891,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFL0qZVE2BVoow6uWQKzITBw7r2UZUQ2lM2LRou4ix3E6ETP2aJoRDCt-hh_gk_gSrp2EPpCQQFlFTuzEOfZ95lyAl2kSScYE8_w4Zh4vaOoJlKteXKIsULGMWWldA-NJNDrlR2fh2QaE3b8wLmlf5lVfz-Z9XU1dbuViLgddntjgw3hIbXQtCga34Dau1yDsjPQ2eMB93rpWuBehDOtYSXkweHNkUWFJEV09nihJqS3wflUk_aFn3kyXvCJ_Du_Cx-7Jm7STT_1Vnffl1xukjv_8avdgu9VIyUHTfB82lN6B3QON1vh8TV4RlyPqnO87sDXs6sPtwvfxqm49iUToguSVLb7l2AfwvKE6IaYkcl1jg2VFIPLntx-viSC4jeD2S8yXqlDWNLfyk8yqhXGsEZUm1dyZBbomqFMTUYhFM5Ttb6JcCkElyLnRZrmcGiUUqQ12t8bV4M2aX7bI-dJ8rqcP4PTw7clw5LVFHzzJWVJ7BRWySKWivGS4nwjK8aAstgFLn8s054HCOfKDIkbNVNFERdZMKlhEc577jD2ETW20egTEF4rSnGF3vuChCgUraV6gjllaxhma9-BF992zRcPtkbmYPA-yS6D0YL-DRIYzbOMpQiuzusioZQKiYfKXK1LLpRPxHuw1ELocp8VeD-Jr4Pp9gaX9vt6CkHH03y1EHv_3nfuwNToZH2fH7ybvn8AdR0br_EpPYbNertQzVLPq_LlbVL8AAuQrBQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtMwGLZgSMANhw1YOc0SiCvSxLGbw-UoVGPQahdMmriJfMoa0dpVlwrKFS_DC_BIPAm_nYR1Q-JiylUUx06cz_6P-X6EXuZZIinlNIjSlAZMkTzgIFeDtARZoFOZ0tK5BsaT5OCYHZ4MTjZKffmkfSmqvpnN-6aa-tzKxVyGXZ5YeDQeEhddS-JwocrwOroBazZOO0O9DSCwiLXuFRYkIMc6ZlIWh28OHTIcMaKvyZNkOXFF3jfF0j-65uWUyQ0ZNLqLPndP36SefOmvatGX3y8RO17p9e6hO61mivebJvfRNW220c6-Aat8vsavsM8V9U74bXRr2NWJ20E_x6u69ShibhQWlSvC5VkI4LyhPMG2xHJdwwXHjoDl7x-_XmOOYTuBbRjbb5XSzkR3chTPqoX17BGVwdXcmwemxqBbY674ohnK9TfRPpWg4vjUGrtcTq3mGtcWulvDqghmza9b-HRpv9bTB-h49O7T8CBoiz8EktGsDhThUuVSE1ZS2Fc4YXAQmrrAZcRkLlisYZ6iWKWgoWqS6cSZS4omRDARUfoQbRlr9C7CEdeECArdRZwN9IDTkggFumbpmGeI6KEX3bcvFg3HR-Fj8ywuzsHSQ3sdLAqYYRdX4Ubb1VlBHCMQGWT_aZE7Tp2E9dCjBkbn47T466H0AsD-NnD03xevAGw8DXgLk8dXvnMP3Tx6Oyo-vp98eIJue05a7156irbq5Uo_A22rFs_9uvoDMLAthQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mutational+and+biochemical+analysis+of+cytochrome+c+%E2%80%B2%2C+a+nitric+oxide-binding+lipoprotein+important+for+adaptation+of+Neisseria+gonorrhoeae+to+oxygen-limited+growth&rft.jtitle=Biochemical+journal&rft.au=TURNER%2C+Susan%C2%A0M.&rft.au=MOIR%2C+James%C2%A0W.%C2%A0B.&rft.au=GRIFFITHS%2C+Lesley&rft.au=OVERTON%2C+Timothy%C2%A0W.&rft.date=2005-06-01&rft.issn=0264-6021&rft.eissn=1470-8728&rft.volume=388&rft.issue=2&rft.spage=545&rft.epage=553&rft_id=info:doi/10.1042%2FBJ20041766&rft.externalDBID=n%2Fa&rft.externalDocID=10_1042_BJ20041766 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0264-6021&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0264-6021&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0264-6021&client=summon |