Activation of SOD-3 is involved in the antioxidant effect of a new class of β-aryl-chalcogenium azide compounds in Caenorhabditis elegans
Abstract Organic selenium, tellurium and sulfur compounds have been studied due to their pharmacological properties. For instance, the β-aryl-chalcogenium azide compounds have demonstrated antitumoral action in vitro. However, yet no pharmacological actions of this class of compounds were determined...
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| Published in | Anais da Academia Brasileira de Ciências Vol. 92; no. suppl 2; p. e20181147 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | Abstract Organic selenium, tellurium and sulfur compounds have been studied due to their pharmacological properties. For instance, the β-aryl-chalcogenium azide compounds have demonstrated antitumoral action in vitro. However, yet no pharmacological actions of this class of compounds were determined in vivo. Caenorhabditis elegans is a nematode that presents innumerable advantages in relation to mammalian models, such as having a small and transparent body, which allows the visualization of its internal anatomy, besides short life and low cost. Based on that, the aim of this work was to investigate the pharmacological and toxicological properties of β-aryl-chalcogenium azide compounds in C. elegans. As well, to evaluate the capacity of organochalcogenium compounds to repair oxidative damage induced by hydrogen peroxide and the possible mechanism of action of these compounds using CF1553 transgenic strain with superoxide dismutase (SOD-3) tagged with GFP. Our results showed that β-aryl-chalcogenium azide have low toxicity in wild-type worms and the pre-treatment protected against the damage induced by hydrogen peroxide at higher tested concentration. Associated with this, we observed that this protection is due in part to the increased expression of the antioxidant enzyme SOD-3. In conclusion, β-aryl-chalcogenium azide compounds caused low toxicity and induced stress-resistance by modulating SOD-3 expression in C. elegans. |
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| AbstractList | Abstract Organic selenium, tellurium and sulfur compounds have been studied due to their pharmacological properties. For instance, the β-aryl-chalcogenium azide compounds have demonstrated antitumoral action in vitro. However, yet no pharmacological actions of this class of compounds were determined in vivo. Caenorhabditis elegans is a nematode that presents innumerable advantages in relation to mammalian models, such as having a small and transparent body, which allows the visualization of its internal anatomy, besides short life and low cost. Based on that, the aim of this work was to investigate the pharmacological and toxicological properties of β-aryl-chalcogenium azide compounds in C. elegans. As well, to evaluate the capacity of organochalcogenium compounds to repair oxidative damage induced by hydrogen peroxide and the possible mechanism of action of these compounds using CF1553 transgenic strain with superoxide dismutase (SOD-3) tagged with GFP. Our results showed that β-aryl-chalcogenium azide have low toxicity in wild-type worms and the pre-treatment protected against the damage induced by hydrogen peroxide at higher tested concentration. Associated with this, we observed that this protection is due in part to the increased expression of the antioxidant enzyme SOD-3. In conclusion, β-aryl-chalcogenium azide compounds caused low toxicity and induced stress-resistance by modulating SOD-3 expression in C. elegans. |
| Author | TABARELLI, GREICE ÁVILA, DAIANA QUINES, CAROLINE B. RODRIGUES, OSCAR E.D. ROOS, DANIEL MOTTA, HODARA S. |
| AuthorAffiliation | Universidade Federal do Pampa Universidade Federal de Santa Maria |
| AuthorAffiliation_xml | – name: Universidade Federal de Santa Maria – name: Universidade Federal do Pampa |
| Author_xml | – sequence: 1 givenname: HODARA S. orcidid: 0000-0003-1818-7179 surname: MOTTA fullname: MOTTA, HODARA S. organization: Universidade Federal do Pampa, Brazil – sequence: 2 givenname: DANIEL orcidid: 0000-0002-3413-8863 surname: ROOS fullname: ROOS, DANIEL organization: Universidade Federal do Pampa, Brazil – sequence: 3 givenname: GREICE orcidid: 0000-0001-9799-1979 surname: TABARELLI fullname: TABARELLI, GREICE organization: Universidade Federal de Santa Maria, Brazil – sequence: 4 givenname: OSCAR E.D. orcidid: 0000-0003-4382-1637 surname: RODRIGUES fullname: RODRIGUES, OSCAR E.D. organization: Universidade Federal de Santa Maria, Brazil – sequence: 5 givenname: DAIANA orcidid: 0000-0002-8673-1909 surname: ÁVILA fullname: ÁVILA, DAIANA organization: Universidade Federal do Pampa, Brazil – sequence: 6 givenname: CAROLINE B. orcidid: 0000-0002-3818-1690 surname: QUINES fullname: QUINES, CAROLINE B. organization: Universidade Federal do Pampa, Brazil |
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| Keywords | C. elegans organochalcogenides selenium superoxide dismutase oxidative stress |
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| Title | Activation of SOD-3 is involved in the antioxidant effect of a new class of β-aryl-chalcogenium azide compounds in Caenorhabditis elegans |
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