Supplementation with D-serine prevents the onset of cognitive deficits in adult offspring after maternal immune activation

• Published in: Scientific reports Vol. 6; no. 1; p. 37261
• Main Authors: Fujita, Yuko, Ishima, Tamaki, Hashimoto, Kenji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.11.2016; Nature Publishing Group
• Subjects: 631/378/1689/1799; 692/699/476/1761; Adolescents; Antagonist drugs; Cognitive ability; D-Serine; Drinking water; Etiology; Glutamic acid receptors (ionotropic); Humanities and Social Sciences; Immune response; Mental disorders; multidisciplinary; N-Methyl-D-aspartic acid receptors; Offspring; Polyinosinic:polycytidylic acid; Psychosis; Schizophrenia; Science; Supplements

Prenatal maternal infection contributes to the etiology of schizophrenia, with D-serine, an endogenous co-agonist of the N -methyl-D-aspartate (NMDA) receptor, playing a role in the pathophysiology of this disease. We examined whether supplementation with D-serine during juvenile and adolescent stag...