Salivary Extracellular MicroRNAs for Early Detection and Prognostication of Esophageal Cancer: A Clinical Study

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 165; no. 4; pp. 932 - 945.e9
• Main Authors: Li, Kai, Lin, Yusheng, Zhou, Yu, Xiong, Xiao, Wang, Lu, Li, Junkuo, Zhou, Fuyou, Guo, Yi, Chen, Shaobin, Chen, Yuping, Tang, Hui, Qiu, Xiaofu, Cai, Songwang, Zhang, Dianzheng, Bremer, Edwin, Jim Yeung, Sai-Ching, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2023
• Subjects: Biomarker; Diagnosis; Esophageal Disease; EVP miRNA; Risk Stratification; RS; Biomarker; OS; Risk Stratification; AUROC; HR; mRNA; ctDNA; ESCC; Esophageal Disease; CHSUMC; DS; EV; CTC; ATH; NPV; PPV; Diagnosis; PFS; EVP miRNA; EVP

Early detection of esophageal squamous cell carcinoma (ESCC) will facilitate curative treatment. We aimed to establish a microRNA (miRNA) signature derived from salivary extracellular vesicles and particles (EVPs) for early ESCC detection and prognostication. Salivary EVP miRNA expression was profil...