Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson’s Disease

• Published in: Scientific reports Vol. 6; no. 1; p. 33738
• Main Authors: Kustrimovic, Natasa, Rasini, Emanuela, Legnaro, Massimiliano, Bombelli, Raffaella, Aleksic, Iva, Blandini, Fabio, Comi, Cristoforo, Mauri, Marco, Minafra, Brigida, Riboldazzi, Giulio, Sanchez-Guajardo, Vanesa, Marino, Franca, Cosentino, Marco
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.09.2016; Nature Publishing Group
• Subjects: 13/1; 13/106; 38/22; 38/90; 631/250/371; 692/308/575; 82/16; Adaptive immunity; CD4 antigen; Cell activation; Dopamine D1 receptors; Dopamine D2 receptors; Humanities and Social Sciences; Immunological memory; Immunosuppressive agents; Immunotherapy; Inflammation; Lewy bodies; Lymphocytes; Lymphocytes T; Memory cells; Motor task performance; Movement disorders; multidisciplinary; Neurodegenerative diseases; Parkinson's disease; Science; Science (multidisciplinary); Substantia nigra; Synuclein; T cell receptors

Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons in substantia nigra pars compacta, α-synuclein (α-syn)-rich intraneuronal inclusions (Lewy bodies), and microglial activation. Emerging evidence suggests that CD4+ T lymphocytes contribute to neuroinflammation in PD. Since the...