Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism

Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decline in sperm quality and a concurrent increased inc...

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Published inScientific reports Vol. 6; no. 1; p. 31281
Main Authors Lea, Richard G., Byers, Andrew S., Sumner, Rebecca N., Rhind, Stewart M., Zhang, Zulin, Freeman, Sarah L., Moxon, Rachel, Richardson, Holly M., Green, Martin, Craigon, Jim, England, Gary C. W.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 09.08.2016
Nature Publishing Group
Subjects
13/106
14
631/136/1425
631/601/1737
692/699/2732/1577
Animals
Biphenyl
Chemicals
Cryptorchidism
Deoxyribonucleic acid
Diethylhexyl Phthalate - chemistry
DNA
Dogs
Environmental Exposure
Explants
Female
Food
Humanities and Social Sciences
Infants
Male
Motility
multidisciplinary
Offspring
PCB
Polychlorinated biphenyls
Polychlorinated Biphenyls - chemistry
Reproduction - drug effects
Science
Secretion
Semen
Semen - drug effects
Semen Analysis
Sperm
Sperm Motility - drug effects
Spermatozoa - drug effects
Testes
Testis - drug effects
Testosterone
Testosterone - metabolism
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Abstract Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995–2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.
AbstractList Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995–2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated bisphenol 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.
Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988-2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995-2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.
Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995–2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.
ArticleNumber 31281
Author Sumner, Rebecca N.
Craigon, Jim
Moxon, Rachel
England, Gary C. W.
Freeman, Sarah L.
Byers, Andrew S.
Green, Martin
Richardson, Holly M.
Lea, Richard G.
Rhind, Stewart M.
Zhang, Zulin
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  organization: Environmental and Biochemical Sciences, The James Hutton Institute
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  organization: National Breeding Centre, Guide Dogs for the Blind Association
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Snippet Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during...
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StartPage 31281
SubjectTerms 13/106
14
631/136/1425
631/601/1737
692/699/2732/1577
Animals
Biphenyl
Chemicals
Cryptorchidism
Deoxyribonucleic acid
Diethylhexyl Phthalate - chemistry
DNA
Dogs
Environmental Exposure
Explants
Female
Food
Humanities and Social Sciences
Infants
Male
Motility
multidisciplinary
Offspring
PCB
Polychlorinated biphenyls
Polychlorinated Biphenyls - chemistry
Reproduction - drug effects
Science
Secretion
Semen
Semen - drug effects
Semen Analysis
Sperm
Sperm Motility - drug effects
Spermatozoa - drug effects
Testes
Testis - drug effects
Testosterone
Testosterone - metabolism
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Title Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism
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https://www.ncbi.nlm.nih.gov/pubmed/27503122
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https://pubmed.ncbi.nlm.nih.gov/PMC4977511
Volume 6
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