Indomethacin has no effect on trigeminally provoked parasympathetic output

• Published in: Cephalalgia Vol. 42; no. 1; pp. 37 - 43
• Main Authors: Möller, Maike, Schröder, Celina, Iwersen-Bergmann, Stefanie, Mehnert, Jan, May, Arne
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2022
• Subjects: Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ibuprofen - pharmacology; Ibuprofen - therapeutic use; Indomethacin - pharmacology; Indomethacin - therapeutic use; Original; Paroxysmal Hemicrania; Trigeminal Autonomic Cephalalgias; hemicrania continua; lacrimation; headache; paroxysmal hemicrania; NSAID

Background Unlike other non-steroidal anti-inflammatory drugs, indomethacin has been shown to be highly effective in two forms of trigeminal autonomic cephalalgias, hemicrania continua and paroxysmal hemicrania and in some forms of idiopathic stabbing headaches. This specificity is unique in the hea...