PHYSIOLOGICAL DISPOSITION OF I.V. MORPHINE IN SHEEP
In a crossover design study we have measured the total body and regional clearances of morphine. Thirteen experiments were performed in four conscious sheep that had been prepared previously with appropriate intravascular cannulae. Morphine (as sulphate pentahydrate) was infused i.v. at 2.5, 5, 10 a...
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Published in | British journal of anaesthesia : BJA Vol. 67; no. 4; pp. 378 - 386 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.10.1991
Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | In a crossover design study we have measured the total body and regional clearances of morphine. Thirteen experiments were performed in four conscious sheep that had been prepared previously with appropriate intravascular cannulae. Morphine (as sulphate pentahydrate) was infused i.v. at 2.5, 5, 10 and 20 mg h−1 to produce constant blood concentrations. Morphine (base) concentrations were measured in blood, urine and tissues with a specific HPLC method. The mean (SEM) total body clearance of morphine was 1.63 (0.21) litre min−1; this comprised 1.01 (0.10) litre min−1 clearance by the liver and 0.55 (0.06) litre min−1 by the kidneys. There was no evidence of dose-dependent clearance or significant extraction of morphine by the lungs, brain, heart, gut or hindquarters at any dose. The kidney clearance of morphine was greater than the 0.21 (0.06) litre min−1 renal clearance determined from the product of the mean total body clearance and the 12.3 (2.4)% of the administered dose recovered as unmetabolized morphine from 48 h urine collection (P <0.05). It was concluded that the liver and kidneys account for the majority of morphine clearance, and that the kidneys both excrete and metabolize morphine. |
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Bibliography: | An abstract of this work was presented in part at the Vlth World Congress on Pain, April 1990, Adelaide, Australia and published in Pain 1990; (Suppl. 5): S175 ark:/67375/HXZ-5910Z7M9-0 istex:5D55C62E977FADA3EE1E919C655397FE51A556F6 ArticleID:67.4.378 Present address, for correspondence: Department of Anaesthesia and Pain Management, The University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-0912 1471-6771 |
DOI: | 10.1093/bja/67.4.378 |