Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response

• Published in: Journal of Neural Transmission Vol. 122; no. 1; pp. 99 - 108
• Main Authors: Domschke, Katharina, Tidow, Nicola, Schwarte, Kathrin, Ziegler, Christiane, Lesch, Klaus-Peter, Deckert, Jürgen, Arolt, Volker, Zwanzger, Peter, Baune, Bernhard T.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.01.2015; Springer Nature B.V
• Subjects: Analysis of Variance; Antidepressive Agents - therapeutic use; Cohort Studies; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - genetics; DNA Methylation - drug effects; DNA Methylation - genetics; Exons - drug effects; Exons - genetics; Female; Genetic Association Studies; Genotype; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Minisatellite Repeats - drug effects; Minisatellite Repeats - genetics; Monoamine Oxidase - genetics; Neurology; Neurosciences; Pharmacogenetics; Psychiatry; Psychiatry and Preclinical Psychiatric Studies - Original Article; Treatment Outcome; Epigenetics; Depression; Monoamine oxidase A; Gender; Methylation; Pharmacoepigenetics

The monoamine oxidase A ( MAO - A ) gene has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of major depressive disorder. In the present analysis, for the first time a pharmacoepigenetic approach was applied investigating the influence of DNA methylation p...