Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights

• Published in: Scientific reports Vol. 6; no. 1; p. 18798
• Main Authors: Singh, Priyanka, Jayaramaiah, Ramesha H., Agawane, Sachin B., Vannuruswamy, Garikapati, Korwar, Arvind M., Anand, Atul, Dhaygude, Vitthal S., Shaikh, Mahemud L., Joshi, Rakesh S., Boppana, Ramanamurthy, Kulkarni, Mahesh J., Thulasiram, Hirekodathakallu V., Giri, Ashok P.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.01.2016; Nature Publishing Group
• Subjects: 101/58; 101/6; 13; 631/154/309/2144; 64/60; 692/308/153; 82; Advanced glycosylation end products; Animals; Blood Glucose; Bovine serum albumin; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Drug Evaluation, Preclinical; Eugenol; Eugenol - pharmacology; Eugenol - therapeutic use; Glucose; Glycated Hemoglobin A - metabolism; Glycation End Products, Advanced - blood; Glycoside Hydrolase Inhibitors - pharmacology; Glycoside Hydrolase Inhibitors - therapeutic use; Guanidines - pharmacology; Hemoglobin; Humanities and Social Sciences; Insulin; Lysine; Male; Mass spectroscopy; Metabolites; Mice, Inbred BALB C; multidisciplinary; Ocimum; Ocimum - chemistry; Ocimum gratissimum; Ocimum kilimandscharicum; Ocimum tenuiflorum; Plant Extracts - pharmacology; Protein structure; Proteomics; Science; Secondary structure; Western blotting; α-Glucosidase

Medicinally important genus Ocimum harbors a vast pool of chemically diverse metabolites. Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. Major metabolites in O . kilimandscharicum , O . tenuiflorum , O . gratissimum were purified, characterized and evaluated...