GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects

Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GS...

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Bibliographic Details
Published inScientific reports Vol. 3; no. 1; p. 2258
Main Authors Wu, Wei, Lu, Jing, Tang, Qiuqin, Zhang, Simin, Yuan, Beilei, Li, Jing, Wu, Di, Sun, Hong, Lu, Chuncheng, Xia, Yankai, Chen, Daozhen, Sha, Jiahao, Wang, Xinru
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.07.2013
Nature Publishing Group
Subjects
631/208/205
631/208/727/2000
692/499
692/699/2732/1577
Adult
Case studies
Case-Control Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Glutathione Transferase - blood
Glutathione Transferase - genetics
GSTM1 protein
GSTT1 protein
Humanities and Social Sciences
Humans
Infertility
Infertility, Male - genetics
Male
Meta-analysis
multidisciplinary
Odds Ratio
Oligozoospermia
Polymorphism, Genetic
Publication Bias
Risk Factors
Science
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ISSN2045-2322
2045-2322
DOI10.1038/srep02258

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Summary:Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, while the null genotype of GSTT1 was significantly associated with normozoospermia and azoospermia. Additionally, significantly elevated GSTT1 expression levels were observed in present genotype compared with null genotype. In the meta-analysis, the null genotype of GSTM1 was associated with a significantly increased risk of male infertility. Furthermore, a stratification analysis showed that the risk of GSTM1 polymorphism was associated with male infertility in both Asian and Caucasian groups. Further studies of GSTM1 and GSTT1 with their biological functions are needed to understand the role of these genes in the development of male infertility.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep02258