Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease

• Published in: Scientific reports Vol. 5; no. 1; p. 8096
• Main Authors: Jiang, Weiwei, Wu, Na, Wang, Xuemei, Chi, Yujing, Zhang, Yuanyuan, Qiu, Xinyun, Hu, Ying, Li, Jing, Liu, Yulan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.02.2015; Nature Publishing Group
• Subjects: 13/51; 147/143; 45/23; 631/326/2565/855; 692/699/1503/1607; Abundance; Adult; Aged; Bacteria - genetics; Bacteria - immunology; CD4 antigen; CD4-Positive T-Lymphocytes - cytology; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; Cross-Sectional Studies; Digestive system; Dysbacteriosis; Dysbiosis; Electron microscopy; Fatty liver; Female; Gastrointestinal tract; Humanities and Social Sciences; Humans; Immune response; Inflammation - pathology; Interferon; Interferon-gamma - genetics; Interferon-gamma - metabolism; Interleukin 6; Interleukin-6 - genetics; Interleukin-6 - metabolism; Intestinal absorption; Intestinal microflora; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine; Liver diseases; Lymphocytes; Lymphocytes T; Male; Microbiota; Middle Aged; Mucosal immunity; multidisciplinary; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - microbiology; Non-alcoholic Fatty Liver Disease - pathology; Portal vein; RNA, Ribosomal, 16S - analysis; rRNA 16S; Science; Sequence Analysis, RNA; Termites; Tight junctions; Tight Junctions - pathology; Transmission electron microscopy; Tumor necrosis factor; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism

Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut microbiota in...