Ambient Fine Particulate Matter Alters Cerebral Hemodynamics in the Elderly

• Published in: Stroke (1970) Vol. 44; no. 6; pp. 1532 - 1536
• Main Authors: Wellenius, Gregory A., Boyle, Luke D., Wilker, Elissa H., Sorond, Farzaneh A., Coull, Brent A., Koutrakis, Petros, Mittleman, Murray A., Lipsitz, Lewis A.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.06.2013
• Subjects: Aged; Aged, 80 and over; Aging - physiology; Biological and medical sciences; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Cohort Studies; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Female; Hemodynamics - drug effects; Hemodynamics - physiology; Humans; Male; Medical sciences; Middle Cerebral Artery - diagnostic imaging; Middle Cerebral Artery - physiology; Nervous system (semeiology, syndromes); Neurology; Particulate Matter - pharmacology; Prospective Studies; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Risk Factors; Stroke - epidemiology; Ultrasonography, Doppler; Vascular diseases and vascular malformations of the nervous system; Vascular Resistance - drug effects; Vascular Resistance - physiology; Human; Doppler ultrasound study; Stroke; Nervous system diseases; cerebrovascular; Cardiovascular disease; Epidemiology; Cerebral disorder; Encephalon; Vascular disease; transcranial Doppler; Central nervous system disease; air pollution; Hemodynamics; Elderly; Cerebrovascular disease; epidemiology; elderly

Short-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular function...