RNA sequencing of cancer reveals novel splicing alterations

• Published in: Scientific reports Vol. 3; no. 1; p. 1689
• Main Authors: Eswaran, Jeyanthy, Horvath, Anelia, Godbole, Sucheta, Reddy, Sirigiri Divijendra, Mudvari, Prakriti, Ohshiro, Kazufumi, Cyanam, Dinesh, Nair, Sujit, Fuqua, Suzanne A. W., Polyak, Kornelia, Florea, Liliana D., Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.04.2013; Nature Publishing Group
• Subjects: 631/114/2785/2302; 631/208/199; 631/208/212/2019; 692/699/67/1347; Base Sequence; Breast cancer; Breast Neoplasms - genetics; Cyclin-dependent kinase 4; ErbB-2 protein; Gene expression; Humanities and Social Sciences; Isoforms; Molecular Sequence Data; multidisciplinary; Neoplasm Proteins - genetics; Protein Isoforms - genetics; Ribonucleic acid; RNA; RNA, Neoplasm - genetics; Science; Sequence Analysis, RNA; Splicing; Transcription; Tumors

Breast cancer transcriptome acquires a myriad of regulation changes and splicing is critical for the cell to “tailor-make” specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-pos...