Characterization of genomic alterations in primary central nervous system lymphomas

• Published in: Journal of neuro-oncology Vol. 140; no. 3; pp. 509 - 517
• Main Authors: Zorofchian, Soheil, El-Achi, Hanadi, Yan, Yuanqing, Esquenazi, Yoshua, Ballester, Leomar Y.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2018; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Bcl-6 protein; Central nervous system; Central Nervous System Neoplasms - genetics; Diagnosis; Female; Frameshift Mutation; Gene rearrangement; Genes; Genetic Predisposition to Disease; Heavy chains; High-Throughput Nucleotide Sequencing; Humans; Immunoglobulins; Laboratory Investigation; Lymphoma; Lymphoma - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Missense mutation; Mutation; Mutation, Missense; MyD88 protein; Nervous system; Neurology; Oncology; p53 Protein; Retrospective Studies; Young Adult; Primary central nervous system lymphoma; Next generation sequencing; Tumor mutation burden; Diffuse large B-cell lymphoma; Gene fusions; MYD88

Purpose Primary central nervous system lymphoma (PCNSL) is a non-Hodgkin lymphoma that affects the central nervous system (CNS). Although previous studies have reported the most common mutated genes in PCNSL, including MYD88 and CD79b , our understanding of genetic characterizations in primary CNS l...