Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3- b ]chromones

• Published in: Anticancer research Vol. 38; no. 8; pp. 4449 - 4457
• Main Authors: Nagai, Junko, Shi, Haixia, Kubota, Yuka, Bandow, Kenjiro, Okudaira, Noriyuki, Uesawa, Yoshihiro, Sakagami, Hiroshi, Tomomura, Mineko, Tomomura, Akito, Takao, Koichi, Sugita, Yoshiaki
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.08.2018
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic drugs; Antitumor agents; Apoptosis; Apoptosis - drug effects; Biological activity; Biotechnology; Cancer; Carcinoma, Squamous Cell - drug therapy; Cell Line; Cell Line, Tumor; Chemical modification; Chemical synthesis; Child; Chromones - chemistry; Chromones - pharmacology; Cytotoxicity; Doxorubicin; Doxorubicin - pharmacology; Female; Humans; Keratinocytes; Materials selection; Mathematical analysis; Melphalan; Mouth Neoplasms - drug therapy; Oral squamous cell carcinoma; Organic chemistry; Polarity; Quantitative Structure-Activity Relationship; Quantum chemistry; Selectivity; Squamous cell carcinoma; Structure-activity relationships; Toxicity; Tumor cell lines; Tumor cells; Tumors; keratinocyte toxicity; Pyrano[4,3-b]chromones; apoptosis induction; tumor selectivity; QSAR analysis; molecular shape; cytotoxicity

4H-1-Benzopyran-4-one (chromone) provides a backbone structure for the chemical synthesis of potent anticancer drugs. Since studies of the biological activity of pyrano[4,3-b]chromones are limited, we investigated a total of 20 pyrano[4,3-b]chromones (10 sets of diastereomers) for their cytotoxicity...