Inhibition of long noncoding RNA Gm41724 alleviates pressure overload-induced cardiac fibrosis by regulating lamina-associated polypeptide 2α

• Published in: Pharmacological research Vol. 188; p. 106677
• Main Authors: Kong, Qihang, Zhou, Junteng, Ma, Chi, Wei, Zisong, Chen, Yan, Cheng, Yue, Wu, Wenchao, Zhou, Zhichao, Tang, Yong, Liu, Xiaojing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2023
• Subjects: Cardiac fibroblast activation; Cardiac fibrosis; Cardiomyopathies - metabolism; Fibroblasts - metabolism; Fibrosis; Humans; Long noncoding RNA; Myocardium - pathology; Pressure overload; RNA binding protein; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Transforming Growth Factor beta1 - metabolism; Cardiac fibroblast activation; Cardiac fibrosis; Pressure overload; Long noncoding RNA; RNA binding protein

Cardiac fibrosis is a pathological process underlying myocardial remodeling and is characterized by excessive deposition of the myocardial extracellular matrix. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of various biological processes. In this study, we investigated the role...