Quantitative multiplexing with nano-self-assemblies in SERS
Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Al...
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| Published in | Scientific reports Vol. 4; no. 1; p. 6785 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Nature Publishing Group UK
30.10.2014
Nature Publishing Group |
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| Abstract | Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating analytes through extraction or chromatography can partially address the problem of interferents, there remains a need for developing direct observational tools capable of multiplexing that can be applied
in situ
. Surface-enhanced Raman Spectroscopy (SERS) is an optical molecular finger-printing technique that has the ability to resolve analytes from within mixtures. SERS has attracted much attention for its potential in multiplexed sensing but it has been limited in its quantitative abilities. Here, we report a facile supramolecular SERS-based method for quantitative multiplex analysis of small organic molecules in aqueous environments such as human urine. |
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| AbstractList | Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating analytes through extraction or chromatography can partially address the problem of interferents, there remains a need for developing direct observational tools capable of multiplexing that can be applied
in situ
. Surface-enhanced Raman Spectroscopy (SERS) is an optical molecular finger-printing technique that has the ability to resolve analytes from within mixtures. SERS has attracted much attention for its potential in multiplexed sensing but it has been limited in its quantitative abilities. Here, we report a facile supramolecular SERS-based method for quantitative multiplex analysis of small organic molecules in aqueous environments such as human urine. Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating analytes through extraction or chromatography can partially address the problem of interferents, there remains a need for developing direct observational tools capable of multiplexing that can be applied in situ. Surface-enhanced Raman Spectroscopy (SERS) is an optical molecular finger-printing technique that has the ability to resolve analytes from within mixtures. SERS has attracted much attention for its potential in multiplexed sensing but it has been limited in its quantitative abilities. Here, we report a facile supramolecular SERS-based method for quantitative multiplex analysis of small organic molecules in aqueous environments such as human urine. |
| ArticleNumber | 6785 |
| Author | Herrmann, Lars O. Baumberg, Jeremy J. Scherman, Oren A. Kasera, Setu Barrio, Jesús del |
| Author_xml | – sequence: 1 givenname: Setu surname: Kasera fullname: Kasera, Setu organization: Department of Chemistry, Melville Laboratory for Polymer Synthesis – sequence: 2 givenname: Lars O. surname: Herrmann fullname: Herrmann, Lars O. organization: Nanophotonics Centre, Cavendish Laboratory, University of Cambridge – sequence: 3 givenname: Jesús del surname: Barrio fullname: Barrio, Jesús del organization: Department of Chemistry, Melville Laboratory for Polymer Synthesis – sequence: 4 givenname: Jeremy J. surname: Baumberg fullname: Baumberg, Jeremy J. organization: Nanophotonics Centre, Cavendish Laboratory, University of Cambridge – sequence: 5 givenname: Oren A. surname: Scherman fullname: Scherman, Oren A. organization: Department of Chemistry, Melville Laboratory for Polymer Synthesis |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25354650$$D View this record in MEDLINE/PubMed |
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| Title | Quantitative multiplexing with nano-self-assemblies in SERS |
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