Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target - Pascale, Silvia; Petrucci, Giovanna; Dragani, Alfredo; Habib, Aida; Zaccardi, Francesco; Pagliaccia, Francesca; Pocaterra, Davide; Ragazzoni, Enzo; Rolandi, Giancarlo; Rocca, Bianca; Patrono, Carlo (Blood, 2012)
Keywords: Acceleration; Adult; Aged; Algorithms; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Aspirin - administration & dosage; Aspirin - therapeutic use; Biological and medical sciences; Cross-Over Studies; Cross-Sectional Studies - statistics & numerical data; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Drug Resistance - drug effects; Female; Half-Life; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Metabolic Networks and Pathways - drug effects; Middle Aged; Molecular Targeted Therapy - methods; Protein Biosynthesis - drug effects; Thrombocythemia, Essential - drug therapy; Thrombocythemia, Essential - metabolism; Thromboxane A2 - biosynthesis; Thromboxane A2 - pharmacokinetics; Prostaglandin-endoperoxide synthase; Hematology; Enzyme; Arachidonic acid derivatives; Enzyme inhibitor; Malignant hemopathy; Biosynthesis; Acetylsalicylic acid; Antiplatelet agent; Myeloproliferative syndrome; Essential thrombocythemia; Eicosanoid; Targeted drug; Oxidoreductases; Salicylates; Thromboxane; Cancer