Association of chromosome 5q21.3 polymorphisms with the exploratory eye movement dysfunction in schizophrenia

• Published in: Scientific reports Vol. 5; no. 1; p. 10299
• Main Authors: Ma, Yuanlin, Li, Jun, Yu, Hao, Wang, Lifang, Lu, Tianlan, Pan, Chao, Han, Yonghua, Zhang, Dai, Yue, Weihua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2015; Nature Publishing Group
• Subjects: 45; 45/43; 5' Untranslated Regions; 692/308/2056; 692/699/476/1799; Adult; alpha-Mannosidase - genetics; Case-Control Studies; Chromosome 5; Chromosomes, Human, Pair 5; Etiology; Eye; Eye movements; Eye Movements - physiology; Female; Genetic Loci; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genotype; Humanities and Social Sciences; Humans; Introns; Linkage Disequilibrium; Male; Mental disorders; multidisciplinary; Phenotype; Polymorphism, Single Nucleotide; Schizophrenia; Schizophrenia - etiology; Schizophrenia - genetics; Science; Single-nucleotide polymorphism

Schizophrenia patients show abnormalities in many eye movement tasks. Among them, exploratory eye movements (EEM) dysfunction seems to be specific to schizophrenia. However the mechanism of EEM disturbances in schizophrenia patients remains elusive. We investigate the relationship between EEM and si...