Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover

• Published in: The American journal of pathology Vol. 190; no. 10; pp. 2018 - 2028
• Main Authors: Zhou, Kecheng, Dichlberger, Andrea, Ikonen, Elina, Blom, Tomas
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2020

Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in most, both healthy and mal...