Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover
Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in most, both healthy and mal...
Saved in:
| Published in | The American journal of pathology Vol. 190; no. 10; pp. 2018 - 2028 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Inc
01.10.2020
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in most, both healthy and malignant, human cells and tissues studied. LAPTM4B-24 lacks the extreme N-terminus and, contrary to LAPTM4B-35, failed to promote cell migration. The endogenous LAPTM4B-24 protein was subject to rapid turnover with a t1/2 of approximately 1 hour. The protein was degraded by both lysosomal and proteasomal pathways, and its levels were increased by the availability of nutrients and lysosomal ceramide. These findings underscore the pathophysiological relevance of the LAPTM4B-24 isoform and identify it as a dynamically regulated effector in lysosomal nutrient signaling. |
|---|---|
| AbstractList | Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in most, both healthy and malignant, human cells and tissues studied. LAPTM4B-24 lacks the extreme N-terminus and, contrary to LAPTM4B-35, failed to promote cell migration. The endogenous LAPTM4B-24 protein was subject to rapid turnover with a t1/2 of approximately 1 hour. The protein was degraded by both lysosomal and proteasomal pathways, and its levels were increased by the availability of nutrients and lysosomal ceramide. These findings underscore the pathophysiological relevance of the LAPTM4B-24 isoform and identify it as a dynamically regulated effector in lysosomal nutrient signaling. Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in most, both healthy and malignant, human cells and tissues studied. LAPTM4B-24 lacks the extreme N-terminus and, contrary to LAPTM4B-35, failed to promote cell migration. The endogenous LAPTM4B-24 protein was subject to rapid turnover with a t1/2 of approximately 1 hour. The protein was degraded by both lysosomal and proteasomal pathways, and its levels were increased by the availability of nutrients and lysosomal ceramide. These findings underscore the pathophysiological relevance of the LAPTM4B-24 isoform and identify it as a dynamically regulated effector in lysosomal nutrient signaling.Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in most, both healthy and malignant, human cells and tissues studied. LAPTM4B-24 lacks the extreme N-terminus and, contrary to LAPTM4B-35, failed to promote cell migration. The endogenous LAPTM4B-24 protein was subject to rapid turnover with a t1/2 of approximately 1 hour. The protein was degraded by both lysosomal and proteasomal pathways, and its levels were increased by the availability of nutrients and lysosomal ceramide. These findings underscore the pathophysiological relevance of the LAPTM4B-24 isoform and identify it as a dynamically regulated effector in lysosomal nutrient signaling. |
| Author | Zhou, Kecheng Dichlberger, Andrea Ikonen, Elina Blom, Tomas |
| Author_xml | – sequence: 1 givenname: Kecheng orcidid: 0000-0003-1753-2524 surname: Zhou fullname: Zhou, Kecheng organization: Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland – sequence: 2 givenname: Andrea orcidid: 0000-0002-2083-3283 surname: Dichlberger fullname: Dichlberger, Andrea organization: Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland – sequence: 3 givenname: Elina orcidid: 0000-0001-8382-1135 surname: Ikonen fullname: Ikonen, Elina organization: Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland – sequence: 4 givenname: Tomas orcidid: 0000-0001-9711-8387 surname: Blom fullname: Blom, Tomas email: tomas.blom@helsinki.fi organization: Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland |
| BookMark | eNqFkcFu1DAQhi1UJLaFN-DgIweSjh032SCEVCpKV1oBqrZna-JMWi-JvdhOpX0PHhiXRRx62YM1Hvn_ftvzn7IT5x0x9lZAKUDU59sStztMD6UECSU0JUD1gi3EhbwopGjFCVsAgCxapeAVO41xm9u6WsKC_V7vo49-In4ZozcWE_X8R_CJrOObgC5ONHW5ElefC6n4KvL0QFlCvZ-sQ5f-y1fRDz5MPG9v5gkzb2OcKXJ0Pb9zPYV7n7tb3Nn-Pf82p2DJpeKW7ufx772bOTj_SOE1ezngGOnNv3rG7q6_bK5uivX3r6ury3VhVLVMBWJTD3UHNdYVmAYrJVQlsBZtDTCAWUpUQyfyiZRyqI2ooKMGFIEcVFd11Rl7d_DdBf8rPzTpyUZD45i_6-eopZKqbZu8svTDQWqCjzHQoI1NmKx3KaAdtQD9FIXe6kMU-ikKDY3OUWRYPYN3wU4Y9sewTweM8gweLQUdTZ6Yod4GMkn33h4z-PjMwIzWWYPjT9ofx_8AOFW9YA |
| CitedBy_id | crossref_primary_10_1111_cas_15362 crossref_primary_10_32604_biocell_2022_021107 crossref_primary_10_1016_j_bbalip_2020_158855 crossref_primary_10_1038_s41389_023_00471_5 crossref_primary_10_1007_s11010_025_05239_6 crossref_primary_10_1111_jcmm_70331 crossref_primary_10_1080_15384047_2023_2230641 crossref_primary_10_1038_s41419_024_06836_x |
| Cites_doi | 10.1038/s41592-019-0512-x 10.1371/journal.pone.0091069 10.1038/nm.2090 10.1534/g3.116.032276 10.1158/1541-7786.MCR-17-0519 10.1038/sj.onc.1206832 10.1021/acscentsci.7b00582 10.1007/s12032-013-0470-6 10.1016/j.tranon.2014.07.001 10.1038/nchembio.1889 10.1016/j.amjsurg.2012.02.003 10.1016/j.canlet.2010.02.006 10.1038/nmeth.f.263 10.1038/onc.2016.189 10.1038/srep13846 10.1371/journal.pone.0027478 10.1016/j.amjsurg.2009.03.031 10.1007/s10549-012-2340-x 10.1016/j.canlet.2004.10.004 10.1038/ncomms8250 10.1194/jlr.R031278 10.1158/0008-5472.CAN-11-0940 10.1007/s11060-017-2369-0 10.1038/s41586-020-2308-7 10.1242/jcs.076240 10.1007/s10495-015-1108-2 10.15252/embj.201489425 10.1038/onc.2010.303 10.1016/j.cell.2014.12.006 10.1002/cncr.25833 10.1016/j.bbalip.2013.09.005 10.1038/nature19356 10.1242/jcs.128132 10.1371/journal.pone.0158715 10.1111/j.1349-7006.2009.01346.x 10.1016/j.canlet.2008.01.025 10.1080/23723556.2016.1169342 10.1371/journal.pone.0121559 10.1038/nature20598 10.1016/j.cellsig.2014.03.004 |
| ContentType | Journal Article |
| Copyright | 2020 American Society for Investigative Pathology Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2020 American Society for Investigative Pathology – notice: Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION 7X8 |
| DOI | 10.1016/j.ajpath.2020.07.003 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1525-2191 |
| EndPage | 2028 |
| ExternalDocumentID | 10_1016_j_ajpath_2020_07_003 S0002944020303369 |
| GrantInformation_xml | – fundername: Sigrid Juselius Foundation funderid: https://doi.org/10.13039/501100006306 – fundername: Academy of Finland grantid: 303771; 266092; 282192; 307415; 312491 funderid: https://doi.org/10.13039/501100002341 – fundername: University of Helsinki funderid: https://doi.org/10.13039/100007797 – fundername: The Liv och Hälsa Foundation |
| GroupedDBID | --- --K -~X .1- .55 .FO .GJ 0R~ 1P~ 23M 2WC 34R 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 7X7 88E 88I 8AF 8C1 8FE 8FH 8FI 8FJ 8R4 8R5 AAEDT AAEDW AAFWJ AAIKJ AALRI AAQFI AAQXK AAXUO AAYWO ABCQX ABJNI ABLJU ABMAC ABOCM ABUWG ABWVN ACGFO ACGOD ACPRK ACRPL ACVFH ADBBV ADCNI ADEZE ADHJS ADMUD ADNMO ADVLN AENEX AEUPX AEVXI AFFNX AFJKZ AFKRA AFPUW AFRHN AFTJW AGCQF AGHFR AGQPQ AHDRD AHMBA AI. AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN AZQEC BAWUL BBNVY BELOY BENPR BHPHI BPHCQ BVXVI C1A CCPQU CS3 DIK DWQXO E3Z EBS EFJIC EFKBS EJD F5P FDB FEDTE FGOYB FYUFA GBLVA GNUQQ GX1 H13 HCIFZ HMCUK HVGLF HX~ HZ~ IH2 IXB J5H KOM KQ8 L7B LID LK8 M1P M2P M41 M7P MVM N9A O9- OG~ OHT OK1 OS. P2P PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO Q2X R2- ROL RPM SEL SES SJN SSZ TIP TR2 UKHRP VH1 WH7 WOQ X7M XH2 Y6R YHG YNH Z5R ZGI ZXP 3V. 6I. AACTN AAFTH AAIAV ABVKL ADPAM AFCTW AGZHU ALXNB NCXOZ ZA5 AAYXX ALIPV CITATION 7X8 |
| ID | FETCH-LOGICAL-c438t-aa76f6b06a630c7a341431a619600f0c82a4fb1c7a222f6c130be704e02f4b3b3 |
| IEDL.DBID | IXB |
| ISSN | 0002-9440 1525-2191 |
| IngestDate | Mon Jul 21 11:37:44 EDT 2025 Tue Jul 01 02:35:08 EDT 2025 Thu Apr 24 23:03:48 EDT 2025 Fri Feb 23 02:47:39 EST 2024 Tue Aug 26 16:57:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c438t-aa76f6b06a630c7a341431a619600f0c82a4fb1c7a222f6c130be704e02f4b3b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-2083-3283 0000-0001-8382-1135 0000-0001-9711-8387 0000-0003-1753-2524 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0002944020303369 |
| PQID | 2424997499 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_2424997499 crossref_citationtrail_10_1016_j_ajpath_2020_07_003 crossref_primary_10_1016_j_ajpath_2020_07_003 elsevier_sciencedirect_doi_10_1016_j_ajpath_2020_07_003 elsevier_clinicalkey_doi_10_1016_j_ajpath_2020_07_003 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | October 2020 2020-10-00 20201001 |
| PublicationDateYYYYMMDD | 2020-10-01 |
| PublicationDate_xml | – month: 10 year: 2020 text: October 2020 |
| PublicationDecade | 2020 |
| PublicationTitle | The American journal of pathology |
| PublicationYear | 2020 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Meng, Wang, Chen, Chang, Zhang, XU, Zhou, Zhang (bib8) 2016; 35 Wang, Xu, Zhou, Zhang (bib36) 2013; 30 Meng, Song, Luo, Yin, Xu, Liu, Zhou, Lou (bib37) 2011; 117 Hashemi, Rezaei, Narouie, Simforoosh, Basiri, Ziaee, Bahari, Taheri (bib38) 2016; 3 Zhou, Dichlberger, Martinez-Seara, Nyholm, Li, Kim, Vattulainen, Ikonen, Blom (bib6) 2018; 4 Milkereit, Persaud, Vanoaica, Guetg, Verrey, Rotin (bib25) 2015; 6 Ng, Mitchell, Kennedy, Chen, McLeod, Ibrahimova, Arruda, Popescu, Gupta, Schimmer, Schuh, Yee, Bullinger, Herold, Görlich, Büchner, Hiddemann, Berdel, Wörmann, Cheok, Preudhomme, Dombret, Metzeler, Buske, Löwenberg, Valk, Zandstra, Minden, Dick, Wang (bib2) 2016; 540 Li, Wei, Pan, Li, Yang, He, Pang, Shan, Xiong, Shao, Zhou (bib4) 2010; 29 Shao, Zhou, Zhang, Zhang, Liu, Rui, Wei, Ye (bib1) 2003; 22 Karczewski, Francioli, Tiao, Cummings, Alföldi, Wang (bib19) 2020; 581 Jiang, Ogretmen (bib28) 2014; 1841 Li, Prasanna, Salo, Vattulainen, Ikonen (bib10) 2019; 16 Zhou, He, Yu, Zhou, Yang, Qu, Rui (bib24) 2010; 199 Cheng, Zheng, Bu, Wu, Zhang, Xing, Wang, Hu, Du, Li, Li, Zhou, Wen, Ji (bib21) 2015; 10 Tan, Sun, Thapa, Liao, Hedman, Anderson (bib5) 2015; 34 Dong, Tamura, Kobayashi, Ando, Sumita, Maehara (bib14) 2017; 132 Neymotin, Ettorre, Gresham (bib13) 2016; 6 Tan, Thapa, Sun, Anderson (bib26) 2015; 160 Vergarajauregui, Martina, Puertollano (bib27) 2011; 124 Milkereit, Rotin (bib7) 2011; 6 Kang, Yin, Jiang, Zhang, Xia, Xue, Huang (bib17) 2012; 204 Pietiäinen, Vassilev, Blom, Wang, Nelson, Bittman, Bäck, Zelcer, Ikonen (bib11) 2013; 126 Kasper, Vogel, Klaman, Gröne, Petersen, Weber, Castaños-Vélez, Staub, Mennerich (bib32) 2005; 224 Dickinson, Flenniken, Ji, Teboul, Wong, White (bib20) 2016; 537 Bird, Kirstein (bib12) 2009; 6 Liu, Xiong, Wei, Yang, Zhou (bib22) 2009; 100 de Ronde, Lips, Mulder, Vincent, Wesseling, Nieuwland, Kerkhoven, Vrancken Peeters, Sonke, Rodenhuis, Wessels (bib34) 2013; 137 Zhou, He, Cui, Zhou, Qu, Zhou, Rui, Yu (bib18) 2008; 264 Li, Zou, Li, Haibe-Kains, Tian, Le, Desmedt, Sotiriou, Szallasi, Iglehart, Richardson, Wang (bib3) 2010; 16 Li, Zhang, Tian, Wang, Zhao, Iglehart, Wang, Richardson (bib33) 2011; 71 Young, Kester, Wang (bib31) 2013; 54 Zhang, Zhou, Xu, Zhang (bib40) 2014; 7 Cheng, Tian, Wu, Xing, Du, Zhou, Zhang, Hao, Wen, Ji (bib39) 2016; 11 Yang, Xiong, Wei, Yang, McNutt, Zhou (bib23) 2010; 294 Blom, Li, Dichlberger, Bäck, Kim, Loizides-Mangold, Riezman, Bittman, Ikonen (bib9) 2015; 11 Zhang, Wei, Liu, Qi, Liang, Qi, Wang, Sheng, Li, Xu (bib15) 2014; 9 Hsieh, Chuang, Yang, Yin, Lin (bib30) 2014; 26 Maki, Fujimoto, Lang, Xu, Behrens, Wistuba, Kadara (bib35) 2015; 5 Harvald, Olsen, Færgeman (bib29) 2015; 20 Wang, Meng, Xu, Zhang (bib16) 2018; 16 Maki (10.1016/j.ajpath.2020.07.003_bib35) 2015; 5 Dickinson (10.1016/j.ajpath.2020.07.003_bib20) 2016; 537 Milkereit (10.1016/j.ajpath.2020.07.003_bib25) 2015; 6 Vergarajauregui (10.1016/j.ajpath.2020.07.003_bib27) 2011; 124 Hashemi (10.1016/j.ajpath.2020.07.003_bib38) 2016; 3 Bird (10.1016/j.ajpath.2020.07.003_bib12) 2009; 6 Zhang (10.1016/j.ajpath.2020.07.003_bib15) 2014; 9 Harvald (10.1016/j.ajpath.2020.07.003_bib29) 2015; 20 Zhang (10.1016/j.ajpath.2020.07.003_bib40) 2014; 7 de Ronde (10.1016/j.ajpath.2020.07.003_bib34) 2013; 137 Zhou (10.1016/j.ajpath.2020.07.003_bib18) 2008; 264 Jiang (10.1016/j.ajpath.2020.07.003_bib28) 2014; 1841 Kasper (10.1016/j.ajpath.2020.07.003_bib32) 2005; 224 Meng (10.1016/j.ajpath.2020.07.003_bib8) 2016; 35 Liu (10.1016/j.ajpath.2020.07.003_bib22) 2009; 100 Dong (10.1016/j.ajpath.2020.07.003_bib14) 2017; 132 Wang (10.1016/j.ajpath.2020.07.003_bib16) 2018; 16 Cheng (10.1016/j.ajpath.2020.07.003_bib21) 2015; 10 Blom (10.1016/j.ajpath.2020.07.003_bib9) 2015; 11 Shao (10.1016/j.ajpath.2020.07.003_bib1) 2003; 22 Ng (10.1016/j.ajpath.2020.07.003_bib2) 2016; 540 Zhou (10.1016/j.ajpath.2020.07.003_bib6) 2018; 4 Wang (10.1016/j.ajpath.2020.07.003_bib36) 2013; 30 Young (10.1016/j.ajpath.2020.07.003_bib31) 2013; 54 Tan (10.1016/j.ajpath.2020.07.003_bib26) 2015; 160 Yang (10.1016/j.ajpath.2020.07.003_bib23) 2010; 294 Hsieh (10.1016/j.ajpath.2020.07.003_bib30) 2014; 26 Li (10.1016/j.ajpath.2020.07.003_bib33) 2011; 71 Milkereit (10.1016/j.ajpath.2020.07.003_bib7) 2011; 6 Karczewski (10.1016/j.ajpath.2020.07.003_bib19) 2020; 581 Cheng (10.1016/j.ajpath.2020.07.003_bib39) 2016; 11 Neymotin (10.1016/j.ajpath.2020.07.003_bib13) 2016; 6 Li (10.1016/j.ajpath.2020.07.003_bib3) 2010; 16 Kang (10.1016/j.ajpath.2020.07.003_bib17) 2012; 204 Li (10.1016/j.ajpath.2020.07.003_bib10) 2019; 16 Meng (10.1016/j.ajpath.2020.07.003_bib37) 2011; 117 Pietiäinen (10.1016/j.ajpath.2020.07.003_bib11) 2013; 126 Li (10.1016/j.ajpath.2020.07.003_bib4) 2010; 29 Zhou (10.1016/j.ajpath.2020.07.003_bib24) 2010; 199 Tan (10.1016/j.ajpath.2020.07.003_bib5) 2015; 34 |
| References_xml | – volume: 137 start-page: 213 year: 2013 end-page: 223 ident: bib34 article-title: SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer publication-title: Breast Cancer Res Treat – volume: 16 start-page: 866 year: 2019 end-page: 869 ident: bib10 article-title: An efficient auxin-inducible degron system with low basal degradation in human cells publication-title: Nat Methods – volume: 6 start-page: 7250 year: 2015 ident: bib25 article-title: LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation publication-title: Nat Commun – volume: 54 start-page: 5 year: 2013 end-page: 19 ident: bib31 article-title: Sphingolipids: regulators of crosstalk between apoptosis and autophagy publication-title: J Lipid Res – volume: 224 start-page: 93 year: 2005 end-page: 103 ident: bib32 article-title: The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression publication-title: Cancer Lett – volume: 264 start-page: 209 year: 2008 end-page: 217 ident: bib18 article-title: Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma publication-title: Cancer Lett – volume: 5 start-page: 13846 year: 2015 ident: bib35 article-title: LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells publication-title: Sci Rep – volume: 35 start-page: 6359 year: 2016 end-page: 6365 ident: bib8 article-title: LAPTM4B: an oncogene in various solid tumors and its functions publication-title: Oncogene – volume: 6 start-page: 3475 year: 2016 end-page: 3483 ident: bib13 article-title: Multiple transcript properties related to translation affect mRNA degradation rates in Saccharomyces cerevisiae publication-title: G3 (Bethesda) – volume: 20 start-page: 658 year: 2015 end-page: 670 ident: bib29 article-title: Autophagy in the light of sphingolipid metabolism publication-title: Apoptosis – volume: 30 start-page: 470 year: 2013 ident: bib36 article-title: Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population publication-title: Med Oncol – volume: 34 start-page: 475 year: 2015 end-page: 490 ident: bib5 article-title: LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation publication-title: EMBO J – volume: 160 start-page: 145 year: 2015 end-page: 160 ident: bib26 article-title: A kinase-independent role for EGF receptor in autophagy initiation publication-title: Cell – volume: 10 start-page: e0121559 year: 2015 ident: bib21 article-title: LAPTM4B-35, a cancer-related gene, is associated with poor prognosis in TNM stages I-III gastric cancer patients publication-title: PLoS One – volume: 9 start-page: e91069 year: 2014 ident: bib15 article-title: Overexpression of LAPTM4B-35: a novel marker of poor prognosis of prostate cancer publication-title: PLoS One – volume: 199 start-page: 515 year: 2010 end-page: 521 ident: bib24 article-title: Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro publication-title: Am J Surg – volume: 11 start-page: 799 year: 2015 end-page: 806 ident: bib9 article-title: LAPTM4B facilitates late endosomal ceramide export to control cell death pathways publication-title: Nat Chem Biol – volume: 3 start-page: e1169342 year: 2016 ident: bib38 article-title: Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population publication-title: Mol Cell Oncol – volume: 132 start-page: 295 year: 2017 end-page: 303 ident: bib14 article-title: LAPTM4B-35 is a novel prognostic factor for glioblastoma publication-title: J Neurooncol – volume: 4 start-page: 548 year: 2018 end-page: 558 ident: bib6 article-title: A ceramide-regulated element in the late endosomal protein LAPTM4B controls amino acid transporter interaction publication-title: ACS Cent Sci – volume: 26 start-page: 1400 year: 2014 end-page: 1408 ident: bib30 article-title: Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle publication-title: Cell Signal – volume: 22 start-page: 5060 year: 2003 end-page: 5069 ident: bib1 article-title: Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma publication-title: Oncogene – volume: 126 start-page: 3961 year: 2013 end-page: 3971 ident: bib11 article-title: NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation publication-title: J Cell Sci – volume: 204 start-page: 677 year: 2012 end-page: 683 ident: bib17 article-title: Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma publication-title: Am J Surg – volume: 537 start-page: 508 year: 2016 end-page: 514 ident: bib20 article-title: High-throughput discovery of novel developmental phenotypes publication-title: Nature – volume: 16 start-page: 857 year: 2018 end-page: 868 ident: bib16 article-title: The transcription factor AP4 promotes oncogenic phenotypes and cisplatin resistance by regulating LAPTM4B expression publication-title: Mol Cancer Res – volume: 16 start-page: 214 year: 2010 end-page: 218 ident: bib3 article-title: Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer publication-title: Nat Med – volume: 581 start-page: 434 year: 2020 end-page: 443 ident: bib19 article-title: The mutational constraint spectrum quantified from variation in 141,456 humans publication-title: Nature – volume: 1841 start-page: 783 year: 2014 end-page: 792 ident: bib28 article-title: Autophagy paradox and ceramide publication-title: Biochim Biophys Acta – volume: 11 start-page: e0158715 year: 2016 ident: bib39 article-title: Relationship between LAPTM4B gene polymorphism and prognosis of patients following tumor resection for colorectal and esophageal cancers publication-title: PLoS One – volume: 100 start-page: 2335 year: 2009 end-page: 2340 ident: bib22 article-title: LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells publication-title: Cancer Sci – volume: 71 start-page: 7481 year: 2011 end-page: 7489 ident: bib33 article-title: Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells publication-title: Cancer Res – volume: 6 start-page: e27478 year: 2011 ident: bib7 article-title: A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins publication-title: PLoS One – volume: 6 year: 2009 ident: bib12 article-title: Real-time, label-free monitoring of cellular invasion and migration with the xCELLigence system publication-title: Nat Methods – volume: 29 start-page: 5785 year: 2010 end-page: 5795 ident: bib4 article-title: LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling publication-title: Oncogene – volume: 294 start-page: 236 year: 2010 end-page: 244 ident: bib23 article-title: Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo publication-title: Cancer Lett – volume: 124 start-page: 459 year: 2011 end-page: 468 ident: bib27 article-title: LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV publication-title: J Cell Sci – volume: 540 start-page: 433 year: 2016 end-page: 437 ident: bib2 article-title: A 17-gene stemness score for rapid determination of risk in acute leukaemia publication-title: Nature – volume: 117 start-page: 2652 year: 2011 end-page: 2658 ident: bib37 article-title: Correlation of LAPTM4B polymorphisms with cervical carcinoma publication-title: Cancer – volume: 7 start-page: 638 year: 2014 end-page: 643 ident: bib40 article-title: Relationship between LAPTM4B gene polymorphism and susceptibility of malignant melanoma in Chinese patients publication-title: Transl Oncol – volume: 16 start-page: 866 year: 2019 ident: 10.1016/j.ajpath.2020.07.003_bib10 article-title: An efficient auxin-inducible degron system with low basal degradation in human cells publication-title: Nat Methods doi: 10.1038/s41592-019-0512-x – volume: 9 start-page: e91069 year: 2014 ident: 10.1016/j.ajpath.2020.07.003_bib15 article-title: Overexpression of LAPTM4B-35: a novel marker of poor prognosis of prostate cancer publication-title: PLoS One doi: 10.1371/journal.pone.0091069 – volume: 16 start-page: 214 year: 2010 ident: 10.1016/j.ajpath.2020.07.003_bib3 article-title: Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer publication-title: Nat Med doi: 10.1038/nm.2090 – volume: 6 start-page: 3475 year: 2016 ident: 10.1016/j.ajpath.2020.07.003_bib13 article-title: Multiple transcript properties related to translation affect mRNA degradation rates in Saccharomyces cerevisiae publication-title: G3 (Bethesda) doi: 10.1534/g3.116.032276 – volume: 16 start-page: 857 year: 2018 ident: 10.1016/j.ajpath.2020.07.003_bib16 article-title: The transcription factor AP4 promotes oncogenic phenotypes and cisplatin resistance by regulating LAPTM4B expression publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-17-0519 – volume: 22 start-page: 5060 year: 2003 ident: 10.1016/j.ajpath.2020.07.003_bib1 article-title: Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma publication-title: Oncogene doi: 10.1038/sj.onc.1206832 – volume: 4 start-page: 548 year: 2018 ident: 10.1016/j.ajpath.2020.07.003_bib6 article-title: A ceramide-regulated element in the late endosomal protein LAPTM4B controls amino acid transporter interaction publication-title: ACS Cent Sci doi: 10.1021/acscentsci.7b00582 – volume: 30 start-page: 470 year: 2013 ident: 10.1016/j.ajpath.2020.07.003_bib36 article-title: Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population publication-title: Med Oncol doi: 10.1007/s12032-013-0470-6 – volume: 7 start-page: 638 year: 2014 ident: 10.1016/j.ajpath.2020.07.003_bib40 article-title: Relationship between LAPTM4B gene polymorphism and susceptibility of malignant melanoma in Chinese patients publication-title: Transl Oncol doi: 10.1016/j.tranon.2014.07.001 – volume: 11 start-page: 799 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib9 article-title: LAPTM4B facilitates late endosomal ceramide export to control cell death pathways publication-title: Nat Chem Biol doi: 10.1038/nchembio.1889 – volume: 204 start-page: 677 year: 2012 ident: 10.1016/j.ajpath.2020.07.003_bib17 article-title: Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma publication-title: Am J Surg doi: 10.1016/j.amjsurg.2012.02.003 – volume: 294 start-page: 236 year: 2010 ident: 10.1016/j.ajpath.2020.07.003_bib23 article-title: Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo publication-title: Cancer Lett doi: 10.1016/j.canlet.2010.02.006 – volume: 6 year: 2009 ident: 10.1016/j.ajpath.2020.07.003_bib12 article-title: Real-time, label-free monitoring of cellular invasion and migration with the xCELLigence system publication-title: Nat Methods doi: 10.1038/nmeth.f.263 – volume: 35 start-page: 6359 year: 2016 ident: 10.1016/j.ajpath.2020.07.003_bib8 article-title: LAPTM4B: an oncogene in various solid tumors and its functions publication-title: Oncogene doi: 10.1038/onc.2016.189 – volume: 5 start-page: 13846 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib35 article-title: LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells publication-title: Sci Rep doi: 10.1038/srep13846 – volume: 6 start-page: e27478 year: 2011 ident: 10.1016/j.ajpath.2020.07.003_bib7 article-title: A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins publication-title: PLoS One doi: 10.1371/journal.pone.0027478 – volume: 199 start-page: 515 year: 2010 ident: 10.1016/j.ajpath.2020.07.003_bib24 article-title: Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro publication-title: Am J Surg doi: 10.1016/j.amjsurg.2009.03.031 – volume: 137 start-page: 213 year: 2013 ident: 10.1016/j.ajpath.2020.07.003_bib34 article-title: SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-012-2340-x – volume: 224 start-page: 93 year: 2005 ident: 10.1016/j.ajpath.2020.07.003_bib32 article-title: The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression publication-title: Cancer Lett doi: 10.1016/j.canlet.2004.10.004 – volume: 6 start-page: 7250 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib25 article-title: LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation publication-title: Nat Commun doi: 10.1038/ncomms8250 – volume: 54 start-page: 5 year: 2013 ident: 10.1016/j.ajpath.2020.07.003_bib31 article-title: Sphingolipids: regulators of crosstalk between apoptosis and autophagy publication-title: J Lipid Res doi: 10.1194/jlr.R031278 – volume: 71 start-page: 7481 year: 2011 ident: 10.1016/j.ajpath.2020.07.003_bib33 article-title: Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-0940 – volume: 132 start-page: 295 year: 2017 ident: 10.1016/j.ajpath.2020.07.003_bib14 article-title: LAPTM4B-35 is a novel prognostic factor for glioblastoma publication-title: J Neurooncol doi: 10.1007/s11060-017-2369-0 – volume: 581 start-page: 434 year: 2020 ident: 10.1016/j.ajpath.2020.07.003_bib19 article-title: The mutational constraint spectrum quantified from variation in 141,456 humans publication-title: Nature doi: 10.1038/s41586-020-2308-7 – volume: 124 start-page: 459 year: 2011 ident: 10.1016/j.ajpath.2020.07.003_bib27 article-title: LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV publication-title: J Cell Sci doi: 10.1242/jcs.076240 – volume: 20 start-page: 658 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib29 article-title: Autophagy in the light of sphingolipid metabolism publication-title: Apoptosis doi: 10.1007/s10495-015-1108-2 – volume: 34 start-page: 475 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib5 article-title: LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation publication-title: EMBO J doi: 10.15252/embj.201489425 – volume: 29 start-page: 5785 year: 2010 ident: 10.1016/j.ajpath.2020.07.003_bib4 article-title: LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling publication-title: Oncogene doi: 10.1038/onc.2010.303 – volume: 160 start-page: 145 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib26 article-title: A kinase-independent role for EGF receptor in autophagy initiation publication-title: Cell doi: 10.1016/j.cell.2014.12.006 – volume: 117 start-page: 2652 year: 2011 ident: 10.1016/j.ajpath.2020.07.003_bib37 article-title: Correlation of LAPTM4B polymorphisms with cervical carcinoma publication-title: Cancer doi: 10.1002/cncr.25833 – volume: 1841 start-page: 783 year: 2014 ident: 10.1016/j.ajpath.2020.07.003_bib28 article-title: Autophagy paradox and ceramide publication-title: Biochim Biophys Acta doi: 10.1016/j.bbalip.2013.09.005 – volume: 537 start-page: 508 year: 2016 ident: 10.1016/j.ajpath.2020.07.003_bib20 article-title: High-throughput discovery of novel developmental phenotypes publication-title: Nature doi: 10.1038/nature19356 – volume: 126 start-page: 3961 year: 2013 ident: 10.1016/j.ajpath.2020.07.003_bib11 article-title: NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation publication-title: J Cell Sci doi: 10.1242/jcs.128132 – volume: 11 start-page: e0158715 year: 2016 ident: 10.1016/j.ajpath.2020.07.003_bib39 article-title: Relationship between LAPTM4B gene polymorphism and prognosis of patients following tumor resection for colorectal and esophageal cancers publication-title: PLoS One doi: 10.1371/journal.pone.0158715 – volume: 100 start-page: 2335 year: 2009 ident: 10.1016/j.ajpath.2020.07.003_bib22 article-title: LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2009.01346.x – volume: 264 start-page: 209 year: 2008 ident: 10.1016/j.ajpath.2020.07.003_bib18 article-title: Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.01.025 – volume: 3 start-page: e1169342 year: 2016 ident: 10.1016/j.ajpath.2020.07.003_bib38 article-title: Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population publication-title: Mol Cell Oncol doi: 10.1080/23723556.2016.1169342 – volume: 10 start-page: e0121559 year: 2015 ident: 10.1016/j.ajpath.2020.07.003_bib21 article-title: LAPTM4B-35, a cancer-related gene, is associated with poor prognosis in TNM stages I-III gastric cancer patients publication-title: PLoS One doi: 10.1371/journal.pone.0121559 – volume: 540 start-page: 433 year: 2016 ident: 10.1016/j.ajpath.2020.07.003_bib2 article-title: A 17-gene stemness score for rapid determination of risk in acute leukaemia publication-title: Nature doi: 10.1038/nature20598 – volume: 26 start-page: 1400 year: 2014 ident: 10.1016/j.ajpath.2020.07.003_bib30 article-title: Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle publication-title: Cell Signal doi: 10.1016/j.cellsig.2014.03.004 |
| SSID | ssj0006380 |
| Score | 2.3843422 |
| Snippet | Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers.... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 2018 |
| Title | Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0002944020303369 https://dx.doi.org/10.1016/j.ajpath.2020.07.003 https://www.proquest.com/docview/2424997499 |
| Volume | 190 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELZWHBCXqqWg0hbkSj3WwrG9cXIEBGJpWaHVrrQ3y3EctIhNVs1y4H_wg5lx4pWAA1VveYwTyzOZ-SaeByE_uXbWaS2ZdblgYPGHLKtyx6RLZCISB1YDE5yvx-nlTF3Nh_MBOYu5MBhW2ev-TqcHbd1fOe5X83i1WGCOLxe5Qv8H1LBMMYlPqiwk8c1PN9oY5ItHCIzUMX0uxHjZO-z7C16i4KGEZ2yd9dY8vVLUwfpcfCQfethIT7qZfSIDX--S7et-Y_wzefrz2DZts_Q0rrcv6Q3WYFjUNNijpV-CY1x7qk6ZUHTUUoB-QOLLpouG2ZCP2gaRLIXD8IufTgNzWmrrkoY-SbcNnE3salH-omMs5w-Wi026rvbw3ilMFiND98js4nx6dsn6hgvMKZmtmbU6rdKCpzaV3GkLFg7whQUfC2BRxV0mrKqKBO4AqqhSYCcvvObKc1GpQhZyn2zVTe2_EFoqVSWicMBGcPAKLKylpc48oA1RpsIdEBnX2bi-Gjk2xbg3MezsznTcMcgdw3GbXB4Qthm16qpxvEM_jCw0MdMUdKMBc_HOOL0Z90Ia_2HkjygpBj5U3H0B1jYPrcE8nBy8tzz_-t9P_0Z28KwLJvxOttZ_H_whgKJ1cQTuwOj3UZD9Z8HHC_I |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBddB1tfxj5p2m7TYI8TkSXFih_X0pBsSRglhbwJWZZHwmKHOn3o_9E_uHeyFdj20LE32zrZQifd_c66D0I-c-2s01oy6zLBQOMP2LDMHJMukYlIHGgNDHCezdPxtfq2HCwPyEWMhUG3yk72tzI9SOvuSb-bzf52tcIYXy4yhfYPiGGZZk_IU0ADGnfnZHm-F8ewwHjEwEge4-eCk5ddY-FfMBMFDzk8Y-2sv_XTH5I6qJ_RS_Kiw430azu0V-TAV6_Js1l3Mv6G3E_vmrqpN57GCfcF_YFJGFYVDQpp4zdgGVeeqnMmFJ00FLAfkPiibt1h9uSTpkYoS-Ey_OOni8CdhtqqoKFQ0s8a7q7sdlV8oXPM5w-qi121Ze3huwsYLLqGviXXo8vFxZh1FReYU3K4Y9bqtExzntpUcqctqDgAGBaMLMBFJXdDYVWZJ9ACsKJMgZ8895orz0WpcpnLd-Swqit_TGihVJmI3AEfwcLLMbOWlnroAW6IIhWuR2ScZ-O6dORYFeOXiX5na9NyxyB3DMdzctkjbN9r26bjeIR-EFloYqgpCEcD-uKRfnrf77fl-A89P8WVYmCn4vELsLa-bQwG4mRgvmXZyX-__SN5Pl7MpmY6mX8_JUfY0noWnpHD3c2tfw8IaZd_CDvgAenzDhk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lysosome+Associated+Protein+Transmembrane+4B-24+Is+the+Predominant+Protein+Isoform+in+Human+Tissues+and+Undergoes+Rapid%2C+Nutrient-Regulated+Turnover&rft.jtitle=The+American+journal+of+pathology&rft.au=Zhou%2C+Kecheng&rft.au=Dichlberger%2C+Andrea&rft.au=Ikonen%2C+Elina&rft.au=Blom%2C+Tomas&rft.date=2020-10-01&rft.issn=0002-9440&rft.volume=190&rft.issue=10&rft.spage=2018&rft.epage=2028&rft_id=info:doi/10.1016%2Fj.ajpath.2020.07.003&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_ajpath_2020_07_003 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9440&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9440&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9440&client=summon |