Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation

Hepatic ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. Therefore, it is important to identity reliable biomarkers to assist early diagnosis of hepatic I/R injury. This study aimed to investigate the potential of serum levels of fibroblast growth fa...

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Published inScientific reports Vol. 6; no. 1; p. 19776
Main Authors Ye, Dewei, Li, Huating, Wang, Yudong, Jia, Weiping, Zhou, Jian, Fan, Jia, Man, Kwan, Lo, Chungmau, Wong, Chiming, Wang, Yu, Lam, Karen S.L., Xu, Aimin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.01.2016
Nature Publishing Group
Subjects
692/53/2423
692/699/1503/1607
Adult
Aged
Biomarkers
Correlation analysis
Female
Fibroblast Growth Factors - blood
Fibroblasts
Growth factors
Humanities and Social Sciences
Humans
Immunology
Ischemia
Liver
Liver Function Tests
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
Male
Middle Aged
multidisciplinary
Reperfusion Injury - blood
Reperfusion Injury - diagnosis
ROC Curve
Science
Time Factors
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/srep19776

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Abstract Hepatic ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. Therefore, it is important to identity reliable biomarkers to assist early diagnosis of hepatic I/R injury. This study aimed to investigate the potential of serum levels of fibroblast growth factor 21 (FGF21) as a biomarker for hepatic I/R injury in patients with liver transplantation. Two independent cohorts of liver transplantation patients were recruited for determination of serum levels of FGF21, ALT and AST. The results demonstrated that serum FGF21 at 2 hours post-reperfusion in cohort-1 exhibited an approximately 20-fold elevation relative to those in healthy subjects. In blood samples dynamically collected in cohort-2, a dramatic increase in serum FGF21 levels (~25-fold) was observed at two hours after surgery, whereas the peak levels of serum ALT and AST were detected only after 24 hours. Temporal correlation analysis demonstrated a significant association of peak serum levels of FGF21 at 2 hours with the magnitude of the increase in both serum ALT and AST levels at 24 hours post transplantation. In conclusion, serum FGF21 may represent a sensitive and specific prognostic biomarker for early detection of I/R injury in patients with liver transplantation.
AbstractList Hepatic ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. Therefore, it is important to identity reliable biomarkers to assist early diagnosis of hepatic I/R injury. This study aimed to investigate the potential of serum levels of fibroblast growth factor 21 (FGF21) as a biomarker for hepatic I/R injury in patients with liver transplantation. Two independent cohorts of liver transplantation patients were recruited for determination of serum levels of FGF21, ALT and AST. The results demonstrated that serum FGF21 at 2 hours post-reperfusion in cohort-1 exhibited an approximately 20-fold elevation relative to those in healthy subjects. In blood samples dynamically collected in cohort-2, a dramatic increase in serum FGF21 levels (~25-fold) was observed at two hours after surgery, whereas the peak levels of serum ALT and AST were detected only after 24 hours. Temporal correlation analysis demonstrated a significant association of peak serum levels of FGF21 at 2 hours with the magnitude of the increase in both serum ALT and AST levels at 24 hours post transplantation. In conclusion, serum FGF21 may represent a sensitive and specific prognostic biomarker for early detection of I/R injury in patients with liver transplantation.
Hepatic ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. Therefore, it is important to identity reliable biomarkers to assist early diagnosis of hepatic I/R injury. This study aimed to investigate the potential of serum levels of fibroblast growth factor 21 (FGF21) as a biomarker for hepatic I/R injury in patients with liver transplantation. Two independent cohorts of liver transplantation patients were recruited for determination of serum levels of FGF21, ALT, and AST. The results demonstrated that serum FGF21 at 2 hours post-reperfusion in cohort-1 exhibited an approximately 20-fold elevation relative to those in healthy subjects. In blood samples dynamically collected in cohort-2, a dramatic increase in serum FGF21 levels (~25-fold) was observed at two hours after surgery, whereas the peak levels of serum ALT and AST were detected only after 24 hours. Temporal correlation analysis demonstrated a significant association of peak serum levels of FGF21 at 2 hours with the magnitude of the increase in both serum ALT and AST levels at 24 hours post transplantation. In conclusion, serum FGF21 may represent a sensitive and specific prognostic biomarker for early detection of I/R injury in patients with liver transplantation.Hepatic ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. Therefore, it is important to identity reliable biomarkers to assist early diagnosis of hepatic I/R injury. This study aimed to investigate the potential of serum levels of fibroblast growth factor 21 (FGF21) as a biomarker for hepatic I/R injury in patients with liver transplantation. Two independent cohorts of liver transplantation patients were recruited for determination of serum levels of FGF21, ALT, and AST. The results demonstrated that serum FGF21 at 2 hours post-reperfusion in cohort-1 exhibited an approximately 20-fold elevation relative to those in healthy subjects. In blood samples dynamically collected in cohort-2, a dramatic increase in serum FGF21 levels (~25-fold) was observed at two hours after surgery, whereas the peak levels of serum ALT and AST were detected only after 24 hours. Temporal correlation analysis demonstrated a significant association of peak serum levels of FGF21 at 2 hours with the magnitude of the increase in both serum ALT and AST levels at 24 hours post transplantation. In conclusion, serum FGF21 may represent a sensitive and specific prognostic biomarker for early detection of I/R injury in patients with liver transplantation.
ArticleNumber 19776
Author Jia, Weiping
Zhou, Jian
Li, Huating
Fan, Jia
Wang, Yu
Lam, Karen S.L.
Ye, Dewei
Man, Kwan
Wong, Chiming
Xu, Aimin
Wang, Yudong
Lo, Chungmau
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Snippet Hepatic ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. Therefore, it is important to identity reliable...
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StartPage 19776
SubjectTerms 692/53/2423
692/699/1503/1607
Adult
Aged
Biomarkers
Correlation analysis
Female
Fibroblast Growth Factors - blood
Fibroblasts
Growth factors
Humanities and Social Sciences
Humans
Immunology
Ischemia
Liver
Liver Function Tests
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
Male
Middle Aged
multidisciplinary
Reperfusion Injury - blood
Reperfusion Injury - diagnosis
ROC Curve
Science
Time Factors
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Title Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation
URI https://link.springer.com/article/10.1038/srep19776
https://www.ncbi.nlm.nih.gov/pubmed/26806156
https://www.proquest.com/docview/1899046625
https://www.proquest.com/docview/1760899014
https://pubmed.ncbi.nlm.nih.gov/PMC4726235
Volume 6
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