Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study

• Published in: Phytomedicine (Stuttgart) Vol. 78; p. 153314
• Main Authors: Tang, Zhuang-Zhuang, Zhang, Yu-Meng, Zheng, Ting, Huang, Ting-Ting, Ma, Teng-Fei, Liu, Yao-Wu
• Format: Journal Article
• Language: English
• Published: Elsevier GmbH 01.11.2020
• Subjects: blood serum; Cell proliferation; cortex; creatinine; Diabetic nephropathy; excretion; glucose; humans; inflammasomes; inflammation; kidneys; NF-κB; PAR-1; rats; Sarsasapogenin; The NLRP3 inflammasome; thrombin; urea nitrogen; uric acid; urine; Cell proliferation; PAR-1; IL; Sar; DM; AGEs; DN; siRNA; RAGE; NF-κB; HMCs; PMSF; FBS; Arg; CMC-Na; The NLRP3 inflammasome; Vor; Diabetic nephropathy; NLRP3; UACR; Sarsasapogenin; HG

Sarsasapogenin (Sar) shows good effects on diabetic nephropathy (DN) through inhibition of the NLRP3 inflammasome, yet the potential mechanism is not well known. This study was designed to explore the regulation of thrombin and/or its receptor protease-activated receptor 1 (PAR-1) on the NLRP3 infla...