Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study - Tang, Zhuang-Zhuang; Zhang, Yu-Meng; Zheng, Ting; Huang, Ting-Ting; Ma, Teng-Fei; Liu, Yao-Wu (Phytomedicine (Stuttgart), 2020)
Keywords: blood serum; Cell proliferation; cortex; creatinine; Diabetic nephropathy; excretion; glucose; humans; inflammasomes; inflammation; kidneys; NF-κB; PAR-1; rats; Sarsasapogenin; The NLRP3 inflammasome; thrombin; urea nitrogen; uric acid; urine; Cell proliferation; PAR-1; IL; Sar; DM; AGEs; DN; siRNA; RAGE; NF-κB; HMCs; PMSF; FBS; Arg; CMC-Na; The NLRP3 inflammasome; Vor; Diabetic nephropathy; NLRP3; UACR; Sarsasapogenin; HG