Celiac anti-type 2 transglutaminase antibodies induce differential effects in fibroblasts from celiac disease patients and from healthy subjects

• Published in: Amino acids Vol. 49; no. 3; pp. 541 - 550
• Main Authors: Paolella, Gaetana, Lepretti, Marilena, Barone, Maria Vittoria, Nanayakkara, Merlin, Di Zenzo, Marina, Sblattero, Daniele, Auricchio, Salvatore, Esposito, Carla, Caputo, Ivana
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.03.2017; Springer Nature B.V
• Subjects: Adolescent; Adult; Amino Acid Sequence; Analytical Chemistry; autoantibodies; Autoantibodies - pharmacology; autoimmunity; Biochemical Engineering; Biochemistry; Biological Transport; Biomedical and Life Sciences; Case-Control Studies; Celiac disease; Celiac Disease - genetics; Celiac Disease - immunology; Celiac Disease - pathology; Dermis - cytology; Dermis - drug effects; Dermis - metabolism; enzyme activity; Female; fibroblasts; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene Expression; gliadin; Gliadin - chemical synthesis; Gliadin - pharmacology; Glutens - chemistry; Glutens - immunology; grains; GTP-Binding Proteins - genetics; GTP-Binding Proteins - immunology; Healthy Volunteers; Humans; immune response; ingestion; innate immunity; intestines; Life Sciences; Male; mucosa; Neurobiology; Original Article; patients; Peptide Fragments - chemical synthesis; Peptide Fragments - pharmacology; peptides; phenotype; Primary Cell Culture; protective effect; protein-glutamine gamma-glutamyltransferase; Proteomics; Transglutaminases - genetics; Transglutaminases - immunology; Celiac disease; Anti-transglutaminase antibodies; Type 2 transglutaminase; Gliadin

Type 2 transglutaminase (TG2) has an important pathogenic role in celiac disease (CD), an inflammatory intestinal disease that is caused by the ingestion of gluten-containing cereals. Indeed, TG2 deamidates specific gliadin peptides, thus enhancing their immunogenicity. Moreover, the transamidating...