Improved Prediction of Amyloid-β and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding

• Published in: Journal of Alzheimer's disease Vol. 91; no. 2; p. 637
• Main Authors: Wu, Jianfeng, Su, Yi, Zhu, Wenhui, Jalili Mallak, Negar, Lepore, Natasha, Reiman, Eric M, Caselli, Richard J, Thompson, Paul M, Chen, Kewei, Wang, Yalin
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: Alzheimer Disease - metabolism; Amyloid beta-Peptides - metabolism; Atrophy - pathology; Biomarkers - cerebrospinal fluid; Hippocampus - pathology; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography - methods; tau Proteins - metabolism; hippocampal multivariate morphometry statistics; Braak34 tau-SUVR; Alzheimer’s disease; Centiloid; dictionary and correntropy-induced sparse coding; tau deposition; amyloid deposition; Braak12 tau-SUVR

Amyloid-β (Aβ) plaques and tau protein tangles in the brain are the defining 'A' and 'T' hallmarks of Alzheimer's disease (AD), and together with structural atrophy detectable on brain magnetic resonance imaging (MRI) scans as one of the neurodegenerative ('N') bio...