Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

• Published in: Journal of molecular neuroscience Vol. 64; no. 1; pp. 129 - 139
• Main Authors: Huang, Lifa, Chen, Chengwei, Zhang, Xin, Li, Xu, Chen, Zupeng, Yang, Chao, Liang, Xiaolong, Zhu, Guochong, Xu, Zhen
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2018; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Anisomycin; Attention; Autophagy; Biomedical and Life Sciences; Biomedicine; Brain; Brain damage; Brain injury; Cell Biology; Cerebral blood flow; Cerebral infarction; Curcumin; Immunoblotting; Immunofluorescence; Infarction; Inflammation; Injection; Interleukin 1; Ischemia; MAP kinase; Neurochemistry; Neurology; Neuroprotection; Neurosciences; Occlusion; Phagocytosis; Proteins; Proteomics; Rats; Reperfusion; Rodents; TLR4 protein; Toll-like receptors; TOR protein; Ventricle; Ventricles (cerebral); Cerebral ischemia-reperfusion injury; Inflammation; Signaling pathway; Crucumin; Autophagy

Curcumin, a polyphenolic compound extracted from Curcuma longa , has drawn attention for its effective bioactivities against ischemia-induced injury. This study aimed to evaluate the neuroprotective effect of curcumin and investigate the underlying mechanism that mediates autophagy and inflammation...