Serotonin and Serotonin Transport in the Regulation of Lactation

Serotonin (5-HT), classically known as a neurotransmitter involved in regulating sleep, appetite, memory, sexual behavior, neuroendocrine function and mood is also synthesized in epithelial cells located in many organs throughout the body, including the mammary gland. The function of epithelial 5-HT...

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Bibliographic Details
Published inJournal of mammary gland biology and neoplasia Vol. 19; no. 1; pp. 139 - 146
Main Authors Marshall, Aaron M., Hernandez, Laura L., Horseman, Nelson D.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.03.2014
Springer Nature B.V
Subjects
Animals
Biological Transport
Cancer Research
Female
Humans
Lactation - metabolism
Mammary Glands, Animal - metabolism
Mammary Glands, Human - metabolism
Medicine
Medicine & Public Health
Oncology
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins - metabolism
SSRI
Involution
Tight junctions
Epithelium
PTHrP
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Summary:Serotonin (5-HT), classically known as a neurotransmitter involved in regulating sleep, appetite, memory, sexual behavior, neuroendocrine function and mood is also synthesized in epithelial cells located in many organs throughout the body, including the mammary gland. The function of epithelial 5-HT is dependent on the expression of the 5-HT receptors in a particular system. The conventional components of a classic 5-HT system are found within the mammary gland; synthetic enzymes (tryptophan hydroxylase I, aromatic amino acid decarboxylase), several 5-HT receptors and the 5-HT reuptake transporter (SERT). In the mammary gland, two actions of 5-HT through two different 5-HT receptor subtypes have been described: negative feedback on milk synthesis and secretion, and stimulation of parathyroid hormone related-protein, a calcium-mobilizing hormone. As with neuronal systems, the regulation of 5-HT activity is multifactorial, but one seminal component is reuptake of 5-HT from the extracellular space following its release. Importantly, the wide availability of selective 5-HT reuptake inhibitors (SSRI) allows the manipulation of 5-HT activity in a biological system. Here, we review the role of 5-HT in mammary gland function, review the biochemistry, genetics and physiology of SERT, and discuss how SERT is vital to the function of the mammary gland.
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ISSN:1083-3021
1573-7039
DOI:10.1007/s10911-013-9304-6