MECT1-MAML2 Fusion Transcript Defines a Favorable Subset of Mucoepidermoid Carcinoma

• Published in: Clinical cancer research Vol. 12; no. 13; pp. 3902 - 3907
• Main Authors: Okabe, Mitsukuni, Miyabe, Satoru, Nagatsuka, Hitoshi, Terada, Akihiro, Hanai, Nobuhiro, Yokoi, Motoo, Shimozato, Kazuo, Eimoto, Tadaaki, Nakamura, Shigeo, Nagai, Noriyuki, Hasegawa, Yasuhisa, Inagaki, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.07.2006
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Mucoepidermoid - classification; Carcinoma, Mucoepidermoid - genetics; Carcinoma, Mucoepidermoid - pathology; Child; clinicopathologic study; Disease-Free Survival; Female; fusion transcript; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - genetics; Humans; Male; MECT1-MAML2; Middle Aged; mucoepidermoid carcinoma; Multivariate Analysis; Neoplasm Staging; Oncogene Proteins, Fusion - genetics; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction - methods; RT-PCR; Salivary Gland Neoplasms - classification; Salivary Gland Neoplasms - genetics; Salivary Gland Neoplasms - pathology; survival analysis; Survival Rate; Transcription, Genetic - genetics

Purpose: Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland. Mucoepidermoid carcinoma translocated gene 1-mastermind-like gene family ( MECT1-MAML2 ) gene fusion was identified from a recurring t(11;19)(q21;p13) translocation, which is often the sole cytogenetic alt...