Serum FGF21 levels are associated with brown adipose tissue activity in humans

• Published in: Scientific reports Vol. 5; no. 1; p. 10275
• Main Authors: Hanssen, Mark J.W., Broeders, Evie, Samms, Ricardo J., Vosselman, Maarten J., van der Lans, Anouk A.J.J., Cheng, Christine C., Adams, Andrew C., van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2015; Nature Publishing Group
• Subjects: 59/78; 631/443/319/1642/2037; 631/443/319/2723; 692/163/2743/2037; Acclimation; Acclimatization; Adipose tissue; Adipose tissue (brown); Adipose Tissue, Brown - physiology; Adult; Animal behavior; Cold; Cold acclimation; Computed tomography; Diabetes mellitus; Dyslipidemia; Energy balance; Energy Metabolism; Female; Fibroblast growth factors; Fibroblast Growth Factors - blood; Homeostasis; Humanities and Social Sciences; Humans; Male; Metabolism; multidisciplinary; Obesity; Pandemics; Positron-Emission Tomography; Science; Temperature effects; Thermogenesis; Tomography, X-Ray Computed; Young Adult

The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT) in humans made this tissue a possible therapeutic target, due to its potentially substantial contributions to energy homeostasis. Fibroblast...